Bioorganic and Medicinal Chemistry Letters p. 349 - 352 (1996)
Update date:2022-08-29
Topics:
Dubuffet, Thierry
Muller, Olivier
Simonet, Serge S.
Descombes, Jean-Jacques
Laubie, Michel
Verbeuren, Tony J.
Lavielle, Gilbert
The synthesis and TP-receptor antagonistic activity of a series of 3,4-disubstituted pyrrolidines is described. The sulfonamide 1h was the most potent TP-receptor antagonist in this series with a pA2 value of 9.5 in isolated guinea pig trachea.
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