Nucleosides, nucleotides and nucleic acids p. 232 - 247 (2018)
Update date:2022-07-30
Topics:
Penjarla, Srishylam
Prasad, S. Rajendra
Reddy, Dhande Sudhakar
Banerjee, Shyamapada
Penta, Santhosh
Sanghvi, Yogesh S.
Regioselective protection of primary hydroxyl group in nucleoside and carbohydrate analogs was accomplished using dimethoxytrityl alcohol (DMTr-OH) or dimethylpixyl alcohol (DMPx-OH) in presence of copper(II)nitrate as a Lewis acid catalyst. Excellent selectivity was observed for the protection of primary hydroxyl group over secondary while glycosidic bond remain unaffected. Utility of this methodology was further exemplified via DMTr- and DMPx-protection of alipahtic acyclic and cyclic diols.
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