Organic Process Research & Development
Article
Framework Programme (FP7/2007−2013) and EFPIA com-
31
panies in kind contribution.
Notes
(
(
15) Pietrowski, M. Curr. Org. Synth. 2012, 9, 470−487.
16) (a) Fey, P.; Mayer, A. C. Chiral synthesis of N-{3,4-diflouro-2-
The authors declare no competing financial interest.
[
(2-fluoro-4-iodophenyl)amino]-6-methoxyphenyl}-1-[2,3-dihydroxy-
ACKNOWLEDGMENTS
propyl]cyclopropanesulfonamides. Patent WO 2012/163799 A1,
December 6, 2012. (b) Xiao, D.; Zhu, L.; Wang, S.; Liang, Z.; Hu,
W. Novel 6-Arylamino pyridine sulfonamides and 6-arylamino
pyrazinone sulfonamides as MEK inhibitors. Patent WO 2010/
■
We would like to thank Karl Robert Boos and Karl-Heinz Baas
for support in reactor design and assembly as well as Volker
Bremer for support in programming the Labmanager. Last but
not least Klaus Petry is acknowledged for his steady support in
reactor operation and trouble shooting.
1
45197 A1, December 23, 2010. (c) Maderna, A.; Vernier, J.-M.
Preparation of (R)- and (S)-N-(3,4-difluoro-2-(2-fluoro-4-iodopheny-
lamino)-6-methoxyphenyl)-1-(2,3-dihydroxypropyl)cyclopropane-1-
sulfonamide and protected derivatives thereof WO 2011/009541 A1,
January 27, 2011.
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