Nucleosides, nucleotides and nucleic acids p. 794 - 799 (2008)
Update date:2022-08-11
Topics:
Schnackerz
Andersen
Dobritzsch
Piskur
Beta-alanine is an intermediate in the reductive degradation of uracil. Recently we have identified and characterized the Saccharomyces kluyveri PYD4 gene and the corresponding enzyme β-alanine aminotransferase (SkPyd4p), highly homologous to eukaryotic γ-aminobutyrate aminotransferase (GABA-AT). S. kluyveri has two aminotransferases, GABA aminotransferase (SkUga1p) with 80% and SkPyd4p with 55% identity to S. cerevisiae GABA-AT. SkPyd4p is a typical pyridoxal phosphate-dependent aminotransferase, specific for α-ketoglutarate (αKG), β-alanine (BAL) and γ-aminobutyrate (GABA), showing a ping-pong kinetic mechanism involving two half-reactions and substrate inhibition. SkUga1p accepts only αKG and GABA but not BAL, thus only SkPydy4p belongs to the uracil degradative pathway. Copyright Taylor & Francis Group, LLC.
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