D. K. Moon et al. / Bioorg. Med. Chem. Lett. 21 (2011) 2773–2775
11. Ashley, E. A.; White, N. J. Curr. Opin. Infect. Dis. 2005, 18, 531.
2775
Acknowledgments
12. de Pilla Varotti, F.; Botelho, A. C. C.; Andrade, A. A.; de Paula, R. C.; Fagundes, E.
M. S.; Valverde, A.; Mayer, L. M. U.; Mendonca, J. S.; de Souza, M. V. N.; Boechat,
N.; Krettli, A. U. Antimicrob. Agents Chemother. 2008, 52, 3868.
13. Adjuik, M.; Babiker, A.; Garner, P.; Olliaro, P.; Taylor, W.; White, N. Lancet 2004,
363, 9.
14. Guthmann, J. P.; Cohuet, S.; Rigutto, C.; Fortes, F.; Saraiva, N.; Kiguli, J.;
Kyomuhendo, J.; Francis, M.; Noel, F.; Mulemba, M.; Balkan, S. Am. J. Trop. Med.
Hyg. 2006, 75, 143.
We thank the NIH (AI 34885 to G.H.P.), the Johns Hopkins
Malaria Research Institute, and the Bloomberg Family Foundation
for financial support (to G.H.P. and to D.S.).
Supplementary data
15. Myint, H. Y.; Ashley, E. A.; Day, N. P. J.; Nosten, F.; White, N. J. Trans. R. Soc. Trop.
Med. Hyg. 2007, 101, 858.
Supplementary data (experimental details and spectroscopic
data for 5 and 6a–6d) associated with this article can be found,
16. Sirima, S. B.; Tiono, A. B.; Gansane, A.; Diarra, A.; Ouedraogo, A.; Konate, A. T.;
Kiechel, J. R.; Morgan, C. C.; Olliaro, P. L.; Taylor, W. R. J. Malar. J. 2009, 8, 48.
17. Sagara, I.; Diallo, A. D.; Lone, M.; Coulibaly, M.; Diawara, S. I.; Guindo, O.;
Maiga, H.; Niambele, M. B.; Sissoko, M.; Dicko, A.; Djimde, A.; Doumbo, O. k.
Am. J. Trop. Med. Hyg. 2008, 79, 655.
18. Woodard, L.; Chang, W.; Chen, X.; Liu, J. O.; Shapiro, T. A.; Posner, G. H. J. Med.
Chem. 2009, 52, 7458.
References and notes
19. Rosenthal, A. S.; Chen, X.; Liu, J. O.; West, D. C.; Hergenrother, P. J.; Shapiro, T.
A.; Posner, G. H. J. Med. Chem. 2009, 52, 1198.
20. Moon, D. K.; Singhal, V.; Kumar, N.; Shapiro, T. A.; Posner, G. H. Drug Dev. Res.
2010, 71, 76.
21. Posner, G. H.; Paik, I.-H.; Sur, S.; McRiner, A. J.; Bortsnik, K.; Xie, S.; Shapiro, T. A.
J. Med. Chem. 2003, 46, 1060.
22. Adam, W.; Heil, M. J. Am. Chem. Soc. 1992, 114, 5591.
23. Greene, T. W.; Wuts, P. G. M. Protective Groups in Organic Synthesis, 3rd ed.;
Wiley-Interscience, 1999. p 440.
24. Jung, M. K.; Lee, S. J. Bioorg. Med. Chem. Lett. 1998, 8, 1003.
25. Sagara, I.; Rulisa, S.; Mbacham, W.; Adam, I.; Sissoko, K.; Maiga, H.; Traore, O.
B.; Dara, N.; Dicko, Y. T.; Dicko, A.; Djimde, A.; Jansen, F. H.; Doumbo, O. K.
Malar. J. 2009, 8, 63.
1. Olliaro, P. L.; Boland, P. B. Clinical Public Health Implications of Antimalarial
Drug Resistance. In Antimalarial Chemotherapy: Mechanisms of Action,
Resistance, and New Directions in Drug Discovery; Rosenthal, P. J., Ed.; Humana
Press: Totowa, NJ, 2001; pp 65–83.
2. Bégué, J. P.; Bonnet-Delpon, D. ChemMedChem 2007, 2, 608.
3. Gelb, M. H. Curr. Opin. Chem. Biol. 2007, 11, 440.
4. Haynes, R. K. Curr. Top. Med. Chem. 2006, 6, 509.
5. Jefford, C. W. Curr. Opin. Invest. Drugs 2004, 5, 866.
6. Klayman, D. L. China Sci. 1985, 228, 1049.
7. O’Neill, P. M.; Posner, G. H. J. Med. Chem. 2004, 47, 2945.
8. Shizhen, L. Compendium of Materia Medica (Bencao Gangm); Foreign Languages
Press: Beijing, China, 2003. p 1593, First Published in Chinese.
9. Tang, Y.; Dong, Y.; Vennerstrom, J. L. Med. Res. Rev. 2004, 24, 425.
10. WHO Guidelines for the Treatment of Malaria; World Health Organization:
Geneva, Switzerland, 2006.
26. Gautam, A.; Ahmed, T.; Batra, V.; Paliwal, J. Curr. Drug Metab. 2009, 10, 289.