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Furan-2-carbohydrazide

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Name

Furan-2-carbohydrazide

EINECS 222-046-2
CAS No. 3326-71-4 Density 1.264 g/cm3
PSA 68.26000 LogP 0.97430
Solubility N/A Melting Point 77-79 °C(lit.)
Formula C5H6N2O2 Boiling Point 279°C(lit.)
Molecular Weight 126.115 Flash Point N/A
Transport Information N/A Appearance Beige crystals
Safety 22-24/25-36/37/39-26 Risk Codes 36/37/38-20/21/22
Molecular Structure Molecular Structure of 3326-71-4 (Furan-2-carbohydrazide) Hazard Symbols HarmfulXn
Synonyms

2-Furoicacid, hydrazide (6CI,7CI,8CI);2-(Hydrazinocarbonyl)furan;2-Furancarbohydrazide;2-Furancarbonyl hydrazide;2-Furoic hydrazide;2-Furoylhydrazine;2-Furylcarbonylhydrazide;2-Furylcarboxylic acid hydrazide;Furan-2-carboxylic hydrazide;NSC11957;NSC 35574;

Article Data 66

Furan-2-carbohydrazide Synthetic route

611-13-2

2-furoic acid methyl ester

3326-71-4

2-furoic acid hydrazide

Conditions
ConditionsYield
With hydrazine hydrate In ethanol for 8h; Reflux;83%
With hydrazine hydrate In ethanol for 5h; Heating;75%
With hydrazine hydrate In ethanol for 5h; Heating;75%
614-99-3

Ethyl 2-furoate

3326-71-4

2-furoic acid hydrazide

Conditions
ConditionsYield
With hydrazine hydrate In ethanol Reflux; Inert atmosphere;80%
With hydrazine hydrate66%
With hydrazine hydrate
88-14-2

2-furanoic acid

3326-71-4

2-furoic acid hydrazide

Conditions
ConditionsYield
With hydrazine hydrate for 0.0472222h; Microwave irradiation;80%
With hydrazine hydrate; triethylamine; fluoro-N,N,N',N'-tetramethylformamidinium hexafluorophosphate In N,N-dimethyl-formamide at 0 - 20℃; for 0.833333h;
Stage #1: 2-furanoic acid With sulfuric acid In ethanol
Stage #2: With hydrazine hydrate
614-99-3

Ethyl 2-furoate

A

3326-71-4

2-furoic acid hydrazide

B

N.N'-difurfuroyl-hydrazine

N.N'-difurfuroyl-hydrazine

Conditions
ConditionsYield
With hydrazine hydrate
2-furoic acid ester

2-furoic acid ester

3326-71-4

2-furoic acid hydrazide

Conditions
ConditionsYield
With hydrazine hydrate
1006894-82-1

N'-[benz-(E)-ylidene]furan-2-ylcarbohydrazide

3326-71-4

2-furoic acid hydrazide

Conditions
ConditionsYield
With water In phosphate buffer; ethanol at 25℃; pH=2.47; Kinetics; Further Variations:; pH-values; Reagents;
In phosphate buffer; ethanol pH=2.47; Kinetics; Further Variations:; pH-values;
88-14-2

2-furanoic acid

A

3326-71-4

2-furoic acid hydrazide

B

n-hexyl halide

n-hexyl halide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: H2SO4
2: H2NNH2*H2O
View Scheme
527-69-5

2-furancarbonyl chloride

3326-71-4

2-furoic acid hydrazide

Conditions
ConditionsYield
With pyridine; hydrazine In tetrahydrofuran at 0 - 50℃; for 2h;
Multi-step reaction with 2 steps
1: Reflux
2: hydrazine hydrate
View Scheme
Multi-step reaction with 2 steps
1: triethylamine / 1 h / 20 °C / Inert atmosphere
2: hydrazine hydrate / methanol / 3 h / Reflux
View Scheme
1006894-82-1

N'-[benz-(E)-ylidene]furan-2-ylcarbohydrazide

A

3326-71-4

2-furoic acid hydrazide

B

100-52-7

benzaldehyde

Conditions
ConditionsYield
With water In ethanol pH=2.47; Rate constant; Phosphoric acid buffer;
With water In ethanol pH=4.48; Rate constant; Citric acid buffer;

N'-[(1E,2E)-3-phenyl-2-propenylidene]-2-furohydrazide

A

14371-10-9

(E)-3-phenylpropenal

B

3326-71-4

2-furoic acid hydrazide

Conditions
ConditionsYield
With water In ethanol pH=2.47; Rate constant; Phosphoric acid buffer;
With water In ethanol pH=4.48; Rate constant; Citric acid buffer;

Furan-2-carbohydrazide Chemical Properties

Molecular Structure of 2-Furancarboxylic acid,hydrazide (CAS NO.3326-71-4):

IUPAC Name: furan-2-carbohydrazide 
Empirical Formula: C5H6N2O2
Molecular Weight: 126.1132
H bond acceptors: 4
H bond donors: 3
Freely Rotating Bonds: 2
Polar Surface Area: 36.69 Å2
Index of Refraction: 1.535
Molar Refractivity: 31.07 cm3
Molar Volume: 99.7 cm3
Surface Tension: 48.8 dyne/cm
Density: 1.264 g/cm3
Flash Point: °C
Enthalpy of Vaporization: kJ/mol
Boiling Point: °C at 760 mmHg
Vapour Pressure: mmHg at 25°C
Melting Point: 77-79 °C(lit.)}
BRN: 114435
InChI
InChI=1/C5H6N2O2/c6-7-5(8)4-2-1-3-9-4/h1-3H,6H2,(H,7,8)
Smiles
c1(C(NN)=O)ccco1
Product Categories: Aromatic Hydrazides, Hydrazines, Hydrazones and Oximes

Furan-2-carbohydrazide Toxicity Data With Reference

 

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 60mg/kg (60mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Journal of Pharmacology and Experimental Therapeutics. Vol. 122, Pg. 110, 1958.

Furan-2-carbohydrazide Safety Profile

Hazard Codes: HarmfulXn
Risk Statements: 36/37/38-20/21/22
R36/37/38:Irritating to eyes, respiratory system and skin. 
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed.
Safety Statements: 22-24/25-36/37/39-26
S22:Do not breathe dust. 
S24/25:Avoid contact with skin and eyes. 
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection. 
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
WGK Germany: 3
RTECS: LV1925000
HS Code: 29321900

Furan-2-carbohydrazide Specification

 2-Furancarboxylic acid,hydrazide , with CAS number of 3326-71-4, can be called 2-furancarbohydrazonicacid ; 2-furancarbonylhydrazide ; 2-furancarboxylicacid,hydrazide ; 2-furoylhydrazide ; 2-furylcarbonylhydrazide ; 2-furylcarboxylicacidhydrazide ; pyromucicacidhydrazide ; AKOS BBS-00004105 .It is a beige crystal.

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