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Cas Database |
| Name |
Glipizide |
EINECS | 249-427-6 |
| CAS No. | 29094-61-9 | Density | 1.34 g/cm3 |
| PSA | 138.53000 | LogP | 4.33160 |
| Solubility | methanol: 1.9 mg/mL | Melting Point |
208-209 °C |
| Formula | C21H27N5O4S | Boiling Point | N/A |
| Molecular Weight | 445.542 | Flash Point | N/A |
| Transport Information | N/A | Appearance | crystalline solid |
| Safety | 24/25-53-36/37-26-25 | Risk Codes | 21-36/38-46-62-63 |
| Molecular Structure |
|
Hazard Symbols |
 Xi, Xn
|
| Synonyms |
Glucotrol;Glydiazinamide;Prestwick_242;N-[2-[4-(cyclohexylcarbamoylsulfamoyl)phenyl]ethyl]-5-methyl-pyrazine-2-carboxamide;Pyrazinecarboxamide,N-[2-[4-[[[(cyclohexylamino) carbonyl]amino]sulfonyl]phenyl]- ethyl]-5-methyl-;TK 1320;Glucotrol (TN);(Glipizide); |
Article Data | 12 |
Glipizide Synthetic route
| Conditions | Yield |
|---|---|
| With iron(III)-acetylacetonate In methanol at 20 - 30℃; for 6h; | 85% |
- 2015-16-9
N-(4-[2-amino-ethyl]-benzenesulfonyl)-N'-cyclohexyl urea
- 41110-33-2
5-methylpyrazine-2-carboxylic acid methyl ester
- 29094-61-9
glipizide
| Conditions | Yield |
|---|---|
| With water; sodium methylate In methanol at 85℃; Concentration; Temperature; Solvent; | 84% |
- 35303-76-5
4-(2-aminoethyl)benzenesulfonamide
- 29094-61-9
glipizide
| Conditions | Yield |
|---|---|
| Multi-step reaction with 4 steps 1: N,N-dimethyl-formamide / 4 h / 20 °C 2: potassium carbonate / acetone / 3 h / 50 - 55 °C 3: hydrogenchloride / methanol / 3 h / 50 - 55 °C 4: sodium methylate; water / methanol / 85 °C View Scheme |
- 258262-54-3
tert-butyl (4-sulfamoyl phenethyl)carbamate
- 29094-61-9
glipizide
| Conditions | Yield |
|---|---|
| Multi-step reaction with 3 steps 1: potassium carbonate / acetone / 3 h / 50 - 55 °C 2: hydrogenchloride / methanol / 3 h / 50 - 55 °C 3: sodium methylate; water / methanol / 85 °C View Scheme |
- 29094-61-9
glipizide
| Conditions | Yield |
|---|---|
| Multi-step reaction with 2 steps 1: hydrogenchloride / methanol / 3 h / 50 - 55 °C 2: sodium methylate; water / methanol / 85 °C View Scheme |
- 29094-61-9
glipizide
- 33288-71-0
N-[2-[4-(amino-sulfonyl)phenyl]ethyl]-5-methylpyrazinecarboxamide
| Conditions | Yield |
|---|---|
| With 3-azapentane-1,5-diamine at 120℃; for 6h; Sealed tube; | 89% |
| With dmap; phthalic anhydride In pyridine for 5h; Reflux; Inert atmosphere; | 63% |
| With pyridine; dmap; phthalic anhydride for 5h; Inert atmosphere; Reflux; | 63% |
- 108-24-7
acetic anhydride
- 29094-61-9
glipizide
| Conditions | Yield |
|---|---|
| With pyridine for 0.25h; | 73% |
| Conditions | Yield |
|---|---|
| Stage #1: glipizide With sodium amide In dimethyl sulfoxide at 20℃; for 0.166667h; Stage #2: diethylenetriaminepentaacetic dianhydride With sodium amide In dimethyl sulfoxide at 20℃; for 4.16667h; | 61.7% |
- 29094-61-9
glipizide
B
- 33288-71-0
N-[2-[4-(amino-sulfonyl)phenyl]ethyl]-5-methylpyrazinecarboxamide
| Conditions | Yield |
|---|---|
| With pyridine; p-toluenesulfonyl chloride Heating; | A 60% B 17% |
Glipizide Chemical Properties
Molecular Structure of Glipizide (CAS NO.29094-61-9):
IUPAC Name:N-[2-[4-(cyclohexylcarbamoylsulfamoyl)phenyl]ethyl]-5-methylpyrazine-2-carboxamide
Molecular Formula: C21H27N5O4S
Molecular Weight: 445.535180 g/mol
Appearance: white solid
Melting Point: 208-209°C
H bond acceptors: 9
H bond donors: 3
Freely Rotating Bonds: 6
Polar Surface Area: 112.16Å2
Index of Refraction: 1.615
Molar Refractivity: 115.92 cm3
Molar Volume: 331.8 cm3
Surface Tension: 66.8 dyne/cm
Density: 1.34 g/cm3
Solubility: methanol 1.9 mg/mL
Categories: Intermediates & Fine Chemicals; Pharmaceuticals; API's; Potassium channel
Glipizide Safety Profile
Safety Information of Glipizide (CAS NO.29094-61-9):
Hazard Codes: 
Xn,
Xi
Risk Statements: 21-36/38-46-62-63
21:Harmful in contact with skin
36/38:Irritating to eyes and skin
46:May cause heritable genetic damage
62:Possible risk of impaired fertility
63:Possible risk of harm to the unborn child
Safety Statements: 24/25-53-36/37-26-25
24/25:Avoid contact with skin and eyes
53:Avoid exposure - obtain special instruction before use
36/37:Wear suitable protective clothing and gloves
26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
25:Avoid contact with eyes
WGK Germany: 3
RTECS: YS7640000
F: 10
Glipizide Specification
Glipizide , with CAS number of 29094-61-9, can be called 2-pyrazinecarboxamide, N-[2-[4-[[[(cyclohexylamino)carbonyl]amino]sulfonyl]phenyl]ethyl]-5-methyl- ; N-(2-{4-[(Cyclohexylcarbamoyl)sulfamoyl]phenyl}ethyl)-5-methyl-2-pyrazinecarboxamide ; Pyrazinecarboxamide, N-(2-(4-((((cyclohexylamino)carbonyl)amino)sulfonyl)phenyl)ethyl)-5-methyl- . Glipizide (CAS NO.29094-61-9) is an oral medium-to-long acting anti-diabetic drug.
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