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| Name |
Laetrile |
EINECS | N/A |
| CAS No. | 1332-94-1 | Density | 1.55g/cm3 |
| PSA | 140.24000 | LogP | -0.83992 |
| Solubility | N/A | Melting Point |
215°C |
| Formula | C14H15 N O7 | Boiling Point | 581.1°Cat760mmHg |
| Molecular Weight | 309.30 | Flash Point | 305.2°C |
| Transport Information | N/A | Appearance | N/A |
| Safety | Human poison by ingestion. Experimental poison by intraperitoneal route. Human systemic effects by ingestion and multiple routes: central nervous system and gastrointestinal changes. Mutation data reported. A controversial treatment for cancer. When heated to decomposition it emits toxic fumes of NOx and CN−. See also NITRILES. | Risk Codes | N/A |
| Molecular Structure |
|
Hazard Symbols | N/A |
| Synonyms |
b-D-Glucopyranosiduronic acid,cyanophenylmethyl, (R)-;Laetrile;Mandelonitrile b-glucuronide;NSC 103055;Vitamin B17; |
Laetrile Chemical Properties
IUPAC: 6-[Cyano(phenyl)methoxy]-3,4,5-trihydroxyoxane-2-carboxylic acid
Laetrile with CAS NO.of 1332-94-1 is also called for Amygdalin ; BRN 5608756 ; NSC 103055 ; Vitamin B(sub 17) ; Vitamin B17 ; beta-D-Glucopyranosiduronic acid, alpha-cyanobenzyl ; l-Mandelonitrile-beta-glucuronoside ; Cyanophenylmethyl-beta-D-glucopyranosiduronic acid ; Mandelonitrile-beta-glucuronide and so on.
CAS:1332-94-1
Molecular Weight: 309.27
Molecular Formula: C14H15NO7
ACD/LogP: -1.17
ACD/BCF (pH 5.5): 1
ACD/BCF (pH 7.4): 1
ACD/KOC (pH 5.5): 1
ACD/KOC (pH 7.4): 1
H bond acceptors: 8
H bond donors: 4
Freely Rotating Bonds: 7
Index of Refraction: 1.634
Molar Refractivity: 71.3 cm3
Molar Volume: 199.2 cm3
Surface Tension: 85.4 dyne/cm
ensity: 1.55 g/cm3
Flash Point: 305.2°C
Enthalpy of Vaporization: 91.41 kJ/mol
Boiling Point: 581.1°C at 760 mmHg
Vapour Pressure: 2.41E-14 mmHg at 25°C
Heavy Atom Count: 22
Formal Charge: 0
Complexity: 442
Isotope Atom Count: 0
Defined Atom StereoCenter Count: 0
Undefined Atom StereoCenter Count: 6
Defined Bond StereoCenter Count: 0
Undefined Bond StereoCenter Count: 0
Covalently-Bonded Unit Count: 1
The molecular structure of Laetrile with CAS NO.of 1332-94-1 :
.bmp)
Laetrile Uses
Laetrile (CAS NO.1332-94-1) is used as antineoplastic agent.
Laetrile Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| man | TDLo | oral | 1286mg/kg/24W (1286mg/kg) | PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE) SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE BEHAVIORAL: MUSCLE WEAKNESS | JAMA, Journal of the American Medical Association. Vol. 238, Pg. 1361, 1977. |
| rabbit | LD50 | intravenous | 687uL/kg (0.687mL/kg) | PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE BEHAVIORAL: ATAXIA | United States Patent Document. Vol. #4337760, |
| rat | LDLo | intraperitoneal | 250mg/kg (250mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION LUNGS, THORAX, OR RESPIRATION: CYANOSIS | JAMA, Journal of the American Medical Association. Vol. 242, Pg. 169, 1979. |
| women | LDLo | oral | 198mg/kg (198mg/kg) | SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS" LUNGS, THORAX, OR RESPIRATION: DYSPNEA | JAMA, Journal of the American Medical Association. Vol. 239, Pg. 1532, 1978. |
| women | TDLo | multiple routes | 4170mg/kg/8W (4170mg/kg) | GASTROINTESTINAL: NAUSEA OR VOMITING SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" | Cancer Treatment Reports. Vol. 62, Pg. 169, 1978. |
| women | TDLo | oral | 60mg/kg (60mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" LIVER: FATTY LIVER DEGERATION | Southern Medical Journal. Vol. 79, Pg. 259, 1986. |
Laetrile Consensus Reports
Cyanide and its compounds are on The Community Right-To-Know List.
Laetrile Safety Profile
Human poison by ingestion. Experimental poison by intraperitoneal route. Human systemic effects by ingestion and multiple routes: central nervous system and gastrointestinal changes. Mutation data reported. A controversial treatment for cancer. When heated to decomposition it emits toxic fumes of NOx and CN−. See also NITRILES.
Laetrile Specification
Removal in wastewater treatment of Laetrile (CAS NO.1332-94-1) :
Total removal:1.85 percent
Total biodegradation:0.09 percent
Total sludge adsorption:1.76 percent
Total to air:0.00 percent
(using 10000 hr Bio P,A,S)
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