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Name	Lisuride Maleate	EINECS	243-387-3
CAS No.	19875-60-6	Density	1.23g/cm³
PSA	125.97000	LogP	2.88200
Solubility	N/A	Melting Point	200° (dec)
Formula	C₂₀H₂₆N₄O•C₄H₄O₄	Boiling Point	603.4°Cat760mmHg
Molecular Weight	454.526	Flash Point	318.7°C
Transport Information	N/A	Appearance	N/A
Safety	Poison by ingestion, subcutaneous, and intravenous routes. Human systemic effects by ingestion: headache, nausea or vomiting, cardiac changes, sweating. Experimental reproductive effects. An experimental teratogen. When heated to decomposition it emits toxic fumes of NO_x.	Risk Codes	N/A
Molecular Structure		Hazard Symbols	N/A
Synonyms	1-((5r,8s)-6-methyl-9,10-didehydro-8-ergolinyl)-3,3-diethylureahydrogenmale;3-(9,10-didehydro-6-methylergolin-8-alpha-yl)-1,1-diethylureamaleate(1:1);3-(9,10-didehydro-6-methylergolin-8-alpha-yl)-1,1-diethyl-uremaleate(1:1);3-(9,10-didehydro-6-methylergolin-8-yl)-1,1-diethylureahydrogenmaleate;cuvalit;lisuridehydrogenmaleate;lisuridemaleate;lysenyl

Lisuride Maleate Synthetic route

Conditions

Conditions	Yield
With water In 1,4-dioxane at 100℃; Rate constant; Product distribution;

Lisuride Maleate Chemical Properties

The Synonyms name of Lisuride Maleate (CAS NO.19875-60-6): 1-((5R,8S)-6-Methyl-9,10-didehydro-8-ergolinyl)-3,3-diethylurea hydrogen maleate ; 3-(9,10-Didehydro-6-methylergolin-8-alpha-yl)-1,1-diethylurea maleate (1:1) ; 3-(9,10-Didehydro-6-methylergolin-8-yl)-1,1-diethylurea hydrogen maleate ; Cuvalit ; Lisuride hydrogen maleate ; Lisuride maleate ; Lysenyl ; Lysenyl bimaleate ; Lysenyl hydrogen maleate ;
Urea, N'-((8-alpha)-9,10-didehydro-6-methylergolin-8-yl)-N,N-diethyl-, (Z)-2-butenedioate
CAS: 19875-60-6
EINECS 243-387-3
Molecular Formula: C₂₄H₃₀N₄O₅
Formula Weight: 454.52 g/mol
Molecular Structure:

Flash Point: 318.7 °C
Boiling Point: 603.4 °C at 760 mmHg

Lisuride Maleate Toxicity Data With Reference

The toxicity of Lisuride Maleate (CAS NO.19875-60-6):

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
human	TDLo	oral	714ng/kg (0.000714mg/kg)	BEHAVIORAL: HEADACHE GASTROINTESTINAL: NAUSEA OR VOMITING	Arzneimittel-Forschung. Drug Research. Vol. 16, Pg. 220, 1966.
man	TDLo	intravenous	1429ng/kg/3M- (0.001429mg/kg)	CARDIAC: OTHER CHANGES GASTROINTESTINAL: NAUSEA OR VOMITING SKIN AND APPENDAGES (SKIN): SWEATING: OTHER	Chest. Vol. 91, Pg. 792, 1987.
mouse	LD₅₀	intravenous	14800ug/kg (14.8mg/kg)	BEHAVIORAL: TREMOR BEHAVIORAL: EXCITEMENT GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS	Kiso to Rinsho. Clinical Report. Vol. 15, Pg. 1165, 1981.
mouse	LD₅₀	oral	90mg/kg (90mg/kg)		United States Patent Document. Vol. #3681497,
mouse	LD₅₀	subcutaneous	82mg/kg (82mg/kg)		United States Patent Document. Vol. #3681497,
rabbit	LD₅₀	oral	123mg/kg (123mg/kg)	BEHAVIORAL: TREMOR BEHAVIORAL: EXCITEMENT GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS	Kiso to Rinsho. Clinical Report. Vol. 15, Pg. 1165, 1981.
rat	LD₅₀	intravenous	1500ug/kg (1.5mg/kg)		United States Patent Document. Vol. #3681497,
rat	LD₅₀	oral	12500ug/kg (12.5mg/kg)		United States Patent Document. Vol. #3681497,
rat	LD₅₀	subcutaneous	3mg/kg (3mg/kg)		United States Patent Document. Vol. #3681497,

Lisuride Maleate Safety Profile

The safety information of Lisuride Maleate (CAS NO.19875-60-6):
Poison by ingestion, subcutaneous, and intravenous routes. Human systemic effects by ingestion: headache, nausea or vomiting, cardiac changes, sweating. Experimental reproductive effects. An experimental teratogen. When heated to decomposition it emits toxic fumes of NO_x.

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