- N-(2-((2-((2-((2-Aminoethyl)amino)ethyl)amino)ethyl)amino)ethyl)octadec-9-enamide monoacetate
- N-(2-((2-((2-((2-Aminoethyl)amino)ethyl)amino)ethyl)amino)ethyl)octadeca-9,12-dien-1-amide
- N-(2-((2-Hydroxyethyl)amino)ethyl)octadeca-9,12-dienamide monoacetate
- N-(2-(2-(Acetylamino)phenyl)ethyl)-1-hydroxynaphthalene-2-carboxamide
- N-(2-(2-METHOXY-1-NAPHTHYL)-1-METHYL-ETHYL)ACETAMIDE
- N-(2-(2-METHOXY-1-NAPHTHYL)-1-METHYL-ETHYL)PROPIONAMIDE
- N-(2-(2-METHOXY-1-NAPHTHYL)-1-METHYL-ETHYL)TRIFLUOROACETAMIDE
- N-(2-(2-METHOXY-1-NAPHTHYL)ETHYL)-CYCLOPROPYLCARBOXAMIDE
- N-(2-(2-METHOXY-1-NAPHTHYL)ETHYL)-PENTANAMIDE
- N-(2-(2-METHOXY-5-METHYLPHENYL)ETHYL)-ROPIONAMIDE
- 5456-13-3Diethyl 2-acetamido-2-[(2-bromo-3,4-dimethoxy-phenyl)methyl]propanedioate
- 5456-19-9Benzene,1-[(diphenylmethyl)thio]-3-methyl-
- 5456-22-4Hydrazinecarboximidamide,2-[(2-hydroxy-5-nitrophenyl)methylene]-N-nitro-
- 54564-31-7Tricyclo[3.3.1.13,7]decane,2-nitro-
- 5456-58-6Acridine,9-chloro-9,10-dihydro-9-(4-methoxyphenyl)-10-phenyl-
- 5456-63-3Cyclohexanol, 2-amino-,hydrochloride, (1R,2R)-rel-
- 5456-67-7D-Galactose, diethyl monothioacetal(9CI)
- 5456-68-8D-galacto-3-Octulose,1,2-dideoxy-, 4,5,6,7,8-pentaacetate
- 54569-28-71,8-Naphthyridine,4-bromo-
- 5456-94-0Benzene,1,5-dibromo-2-methoxy-4-methyl-
Hot Products
- 54571-67-42-Pyrrolidone-5-carboxylic acid sodium salt
- 54578-28-8THERMINOL66
- 54578-91-52-Butenedioic acid (2Z)-, polymer with methoxyethene, butyl ester
- 5460-29-7N-(3-Bromopropyl)phthalimide
- 546091-17-25-Bromo-N-(sec-butyl)-2-furamide
- 54617-29-7L-Isoleucine, N-(1-oxohexadecyl)-
- 54626-91-42-Propenoic acid, 2-methyl-, methyl ester, polymer with ethenol and ethenyl acetate
- 54628-89-61-(4-aminophenyl)-2,3-dihydro-1,3,3-trimethyl-1H-inden-5-amine
- 104987-11-3Tacrolimus
- 141-53-7Sodium formate
- 8001-54-5Quaternary ammonium compounds, alkylbenzyldimethyl, chlorides
- 9003-39-8Povidone
- 10161-34-9Trenbolone acetate
- 402957-28-2Telaprevir
- 68-19-9Cyanocobalamin
|
Basic Information |
|
Post buying leads |
|
Suppliers |
|
Cas Database |
| Name |
N-(2,3-Epoxypropyl)phthalimide |
EINECS | 226-710-2 |
| CAS No. | 5455-98-1 | Density | 1.446 g/cm3 |
| PSA | 49.91000 | LogP | 0.61930 |
| Solubility | N/A | Melting Point |
92-98 °C |
| Formula | C11H9NO3 | Boiling Point | 347.4 °C at 760 mmHg |
| Molecular Weight | 203.197 | Flash Point | 163.9 °C |
| Transport Information | N/A | Appearance | white crystalline powder |
| Safety | 26-39 | Risk Codes | 41 |
| Molecular Structure |
|
Hazard Symbols |
 Xi
|
| Synonyms |
1H-Isoindole-1,3(2H)-dione,2-(oxiranylmethyl)- (9CI);Phthalimide, N-(2,3-epoxypropyl)- (8CI);(Phthalimidomethyl)oxirane;2,3-Epoxypropylphthalimide;2-(Phthalimidomethyl)oxirane;2-[(Oxiranyl)methyl]isoindole-1,3-dione;DenacolEX 731;N-(2,3-Epoxypropan-1-yl)phthalimide;N-(2,3-Epoxypropyl)phthalimide;N-Glycidylphthalimide;N-Oxiranylmethylphthalimide;NSC 7244;N-(2,3-Epoxypropyl) phthalmide; |
Article Data | 29 |
N-(2,3-Epoxypropyl)phthalimide Synthetic route
| Conditions | Yield |
|---|---|
| With 3-chloro-benzenecarboperoxoic acid In dichloromethane | 99% |
| With 3-chloro-benzenecarboperoxoic acid In dichloromethane for 72h; | 92% |
| With 3-chloro-benzenecarboperoxoic acid In dichloromethane at 20℃; for 16h; |
- 19667-37-9, 34839-11-7, 148857-42-5, 148857-44-7
2-(3-chloro-2-hydroxypropyl)-1H-isoindole-1,3(2H)-dione
- 5455-98-1
2-oxiranylmethylisoindole-1,3-dione
| Conditions | Yield |
|---|---|
| With potassium fluoride supported on Celite In acetonitrile for 0.5h; Reflux; regioselective reaction; | 98% |
| With potassium carbonate In toluene Reflux; |
| Conditions | Yield |
|---|---|
| for 8h; Reflux; | 95% |
| In N,N-dimethyl-formamide at 20℃; for 10h; | 90% |
| at 120℃; for 5h; | 80% |
| Conditions | Yield |
|---|---|
| With potassium carbonate at 120℃; for 5h; | 89% |
| With potassium fluoride; 3-butyl-1-methyl-1H-imidazol-3-ium hexafluorophosphate at 85℃; for 6h; | 87% |
| Stage #1: phthalimide With potassium hydroxide In ethanol; water at 75 - 85℃; Stage #2: epichlorohydrin at 120℃; | 68.54% |
| With triphenylphosphine; diethylazodicarboxylate In tetrahydrofuran at 0 - 15℃; for 12h; Inert atmosphere; | 36.6% |
- 136918-14-4
phthalimide
- 106-89-8
epichlorohydrin
A
- 5455-98-1
2-oxiranylmethylisoindole-1,3-dione
B
- 19667-37-9, 34839-11-7, 148857-42-5, 148857-44-7
2-(3-chloro-2-hydroxypropyl)-1H-isoindole-1,3(2H)-dione
| Conditions | Yield |
|---|---|
| With potassium fluoride on basic alumina In 2-methyltetrahydrofuran for 3h; Inert atmosphere; Reflux; chemoselective reaction; | A 12% B 86% |
| With aluminum oxide In 1-methyl-pyrrolidin-2-one at 64 - 68℃; |
| Conditions | Yield |
|---|---|
| With triphenylphosphine; diethylazodicarboxylate In tetrahydrofuran Mitsunobu reaction; | 75% |
| With triphenylphosphine; diethylazodicarboxylate In tetrahydrofuran for 18h; Ambient temperature; | 72% |
- 1074-82-4
potassium phtalimide
- 3132-64-7
1,2-Epoxy-3-bromopropane
- 5455-98-1
2-oxiranylmethylisoindole-1,3-dione
| Conditions | Yield |
|---|---|
| In 1,2-dimethoxyethane at 120℃; for 3h; | 51% |
| Conditions | Yield |
|---|---|
| Multi-step reaction with 2 steps 1: 80.2 percent / dimethylformamide / 50 °C 2: 92 percent / m-chloroperbenzoic acid / CH2Cl2 / 72 h View Scheme | |
| Multi-step reaction with 2 steps 1: N,N-dimethyl-formamide / 16 h / 80 °C 2: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 16 h / 20 °C View Scheme |
| Conditions | Yield |
|---|---|
| Multi-step reaction with 2 steps 1: 82 percent / 18-crown-6 / toluene 2: 99 percent / mCPBA / CH2Cl2 View Scheme |
- 118712-54-2
glycidyl p-toluenesulfonate
- 5455-98-1
2-oxiranylmethylisoindole-1,3-dione
N-(2,3-Epoxypropyl)phthalimide Consensus Reports
Reported in EPA TSCA Inventory.
N-(2,3-Epoxypropyl)phthalimide Specification
The IUPAC name of N-(2,3-Epoxypropyl)phthalimide is 2-(oxiran-2-ylmethyl)isoindole-1,3-dione. With the CAS registry number 5455-98-1, it is also named as (Phthalimidomethyl)oxirane. The product's categories are Fused Ring Systems; Others Chemical Reagents, and the other registry number is 142176-79-2. Besides, it is white crystalline powder, which should be sealed in a dark, ventilated and dry place at 0-6 °C. In addition, its molecular formula is C11H9NO3 and molecular weight is 203.19.
The other characteristics of this product can be summarized as: (1)EINECS: 226-710-2; (2)ACD/LogP: 1.60; (3)# of Rule of 5 Violations: 0; (4)ACD/LogD (pH 5.5): 1.6; (5)ACD/LogD (pH 7.4): 1.6; (6)ACD/BCF (pH 5.5): 9.76; (7)ACD/BCF (pH 7.4): 9.76; (8)ACD/KOC (pH 5.5): 177.71; (9)ACD/KOC (pH 7.4): 177.71; (10)#H bond acceptors: 4; (11)#H bond donors: 0; (12)#Freely Rotating Bonds: 2; (13)Index of Refraction: 1.648; (14)Molar Refractivity: 51.16 cm3; (15)Molar Volume: 140.4 cm3; (16)Surface Tension: 64.5 dyne/cm; (17)Density: 1.446 g/cm3; (18)Flash Point: 163.9 °C; (19)Melting Point: 92-98 °C; (20)Enthalpy of Vaporization: 59.17 kJ/mol; (21)Boiling Point: 347.4 °C at 760 mmHg; (22)Vapour Pressure: 5.38E-05 mmHg at 25 °C.
Preparation of N-(2,3-Epoxypropyl)phthalimide: this chemical can be prepared by chloromethyl-oxirane and phthalimide; potassium salt.
.jpg)
This reaction needs dimethylformamide at temperature of 20 °C. The reaction time is 10 hours. The yield is 90 %.
Uses of N-(2,3-Epoxypropyl)phthalimide: it can react with 2-nitro-1H-imidazole to get 2-[2-hydroxy-3-(2-nitro-imidazol-1-yl)-propyl]-isoindole-1,3-dione.
.jpg)
This reaction needs K2CO3 and ethanol by heating for 6 hours. The yield is 59 %.
When you are using this chemical, please be cautious about it as the following: it is risk of serious damage to eyes. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. And you should wear eye/face protection.
People can use the following data to convert to the molecule structure.
(1)Canonical SMILES: C1C(O1)CN2C(=O)C3=CC=CC=C3C2=O
(2)InChI: InChI=1S/C11H9NO3/c13-10-8-3-1-2-4-9(8)11(14)12(10)5-7-6-15-7/h1-4,7H,5-6H2
(3)InChIKey: DUILGEYLVHGSEE-UHFFFAOYSA-N
The toxicity data is as follows:
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| rat | LCLo | inhalation | 4400mg/m3/4H (4400mg/m3) | SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES | Journal of the American College of Toxicology. Vol. 4(1), Pg. 219, 1985. |
| rat | LD50 | oral | 4700mg/kg (4700mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ATAXIA GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS | Toxicology and Applied Pharmacology. Vol. 51, Pg. 197, 1979. |
What can I do for you?
Get Best Price
