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N,N-Dimethylglycine

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Name

N,N-Dimethylglycine

EINECS 214-267-8
CAS No. 1118-68-9 Density 1.069 g/cm3
PSA 40.54000 LogP -0.36740
Solubility soluble in water Melting Point 178-182 °C(lit.)
Formula C4H9NO2 Boiling Point 175.2 °C at 760 mmHg
Molecular Weight 103.121 Flash Point 59.8 °C
Transport Information N/A Appearance white to slightly yellow crystalline powder
Safety 24/25-36/37-26 Risk Codes 22-36/37/38
Molecular Structure Molecular Structure of 1118-68-9 (N,N-Dimethylglycine) Hazard Symbols HarmfulXn,IrritantXi
Synonyms

(Dimethylamino)aceticacid;2-(Dimethylamino)acetic acid;2-(N,N-Dimethylamino)acetic acid;DMG;Dimethylglycine;N,N-Dimethylaminoacetic acid;N-Methylsarcosine;N,N-Dimthylglycine;

Article Data 52

N,N-Dimethylglycine Synthetic route

50-00-0

formaldehyd

56-40-6

glycine

1118-68-9

dimethylaminoacetic acid

Conditions
ConditionsYield
With hydrogen; palladium on activated charcoal In ethanol; water under 2068.6 Torr; for 10h; Ambient temperature;98%
With sodium dihydrogenphosphate; zinc at 30℃; for 1h;94%
With sodium tetrahydroborate In 2,2,2-trifluoroethanol for 24h; Reflux;91%
33229-89-9

N,N-dimethylglycine ethyl ester

1118-68-9

dimethylaminoacetic acid

Conditions
ConditionsYield
With sodium hydroxide In water Heating;30%
108-01-0

2-(N,N-dimethylamino)ethanol

1118-68-9

dimethylaminoacetic acid

Conditions
ConditionsYield
With chromium(VI) oxide; sulfuric acid; acetone
6027-13-0

L-homocysteine

107-43-7

betaine

A

1118-68-9

dimethylaminoacetic acid

B

63-68-3

L-methionine

Conditions
ConditionsYield
in Gegenwart von Leber-Praeparaten;
926-64-7

N,N-Dimethylamino acetonitrile

1118-68-9

dimethylaminoacetic acid

Conditions
ConditionsYield
With potassium hydroxide at 100℃;
89222-12-8

2-dimethylaminomalonic acid diethyl ester

1118-68-9

dimethylaminoacetic acid

Conditions
ConditionsYield
With hydrogenchloride
124-40-3

dimethyl amine

107-16-4

glycolonitrile

1118-68-9

dimethylaminoacetic acid

Conditions
ConditionsYield
anschliessend Behandeln mit Barytwasser;
124-40-3

dimethyl amine

79-11-8

chloroacetic acid

1118-68-9

dimethylaminoacetic acid

50-00-0

formaldehyd

56-40-6

glycine

A

107-97-1

sarcosine

B

1118-68-9

dimethylaminoacetic acid

Conditions
ConditionsYield
With hydrogenchloride; tin
124225-44-1

1-methyl-4-(phenylacetyl)pyridinium cation

20837-43-8

dimethylaminoacetate

A

1118-68-9

dimethylaminoacetic acid

B

114444-46-1

C14H13NO

Conditions
ConditionsYield
In water at 25℃; Equilibrium constant; Rate constant; Thermodynamic data; ΔH0, ΔS0, ΔG0; kinetics, other temperatures; activation parameters: ΔH(excit.), ΔS(excit.), ΔG(excit.);

N,N-Dimethylglycine Specification

The CAS register number of Glycine, N,N-dimethyl- is 1118-68-9. It also can be called as N,N-Dimethylglycine and the systematic name about this chemical is 2-(dimethylamino)acetic acid. The molecular formula about this chemical is C4H9NO2 and the molecular weight is 103.12. It belongs to the Miscellaneous Biochemicals. This chemical can be used as pharmaceutical intermediate. This chemical is stable under normal temperatures and pressures, please avoid contact with oxidizing agents and water. If you want to store it, please keep it in a closed container and store it in a cool, dry place.

Physical properties about Glycine, N,N-dimethyl- are: (1)ACD/LogP: -0.30; (2)ACD/LogD (pH 5.5): -2.8; (3)ACD/LogD (pH 7.4): -2.8; (4)ACD/BCF (pH 5.5): 1; (5)ACD/BCF (pH 7.4): 1; (6)ACD/KOC (pH 5.5): 1; (7)ACD/KOC (pH 7.4): 1; (8)#H bond acceptors: 3; (9)#H bond donors: 1; (10)#Freely Rotating Bonds: 2; (11)Polar Surface Area: 29.54Å2; (12)Index of Refraction: 1.448; (13)Molar Refractivity: 25.86 cm3; (14)Molar Volume: 96.4 cm3; (15)Polarizability: 10.25x10-24cm3; (16)Surface Tension: 37.5 dyne/cm; (17)Enthalpy of Vaporization: 45.38 kJ/mol; (18)Boiling Point: 175.2 °C at 760 mmHg; (19)Vapour Pressure: 0.556 mmHg at 25°C.

Preparation: this chemical can be prepared by N,N-dimethyl-glycine ethyl ester. This reaction will need reagent NaOH and solvent H2O at heating. The yield is about 30%.

Uses of Glycine, N,N-dimethyl-: it can be used to produce N,N-dimethyl-N-oxy-glycine. This reaction will need reagent aq. H2O2 and solvent acetic acid.

When you are using this chemical, please be cautious about it as the following:
This chemical is harmful if swallowed and it is irritating to eyes, respiratory system and skin. When you are using it, wear suitable protective clothing and gloves, you also need avoid contact with skin and eyes. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.

You can still convert the following datas into molecular structure:
(1)SMILES: O=C(O)CN(C)C
(2)InChI: InChI=1/C4H9NO2/c1-5(2)3-4(6)7/h3H2,1-2H3,(H,6,7)
(3)InChIKey: FFDGPVCHZBVARC-UHFFFAOYAX
(4)Std. InChI: InChI=1S/C4H9NO2/c1-5(2)3-4(6)7/h3H2,1-2H3,(H,6,7)
(5)Std. InChIKey: FFDGPVCHZBVARC-UHFFFAOYSA-N

The toxicity data is as follows:

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
rat LD50 oral > 650mg/kg (650mg/kg) BEHAVIORAL: ATAXIA

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

BLOOD: CHANGES IN SPLEEN
Acute Toxicity Data. Journal of the American College of Toxicology, Part B. Vol. 1, Pg. 199, 1992.

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