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Cas Database |
| Name |
Nafamostat mesylate |
EINECS | 692-168-2 |
| CAS No. | 82956-11-4 | Density | N/A |
| PSA | 200.82000 | LogP | 4.90630 |
| Solubility | N/A | Melting Point |
259-261 °C |
| Formula | C21H25N5O8S2 | Boiling Point | 637.2 °C at 760 mmHg |
| Molecular Weight | 539.59 | Flash Point | 339.1 °C |
| Transport Information | N/A | Appearance | Tan to pale orange solid |
| Safety | Risk Codes | N/A | |
| Molecular Structure |
|
Hazard Symbols | N/A |
| Synonyms |
Benzoic acid, 4-((aminoiminomethyl)amino)-, 6-(aminoiminomethyl)-2-naphthalenyl ester, dimethanesulfonate;Ronastat;Nafamostat mesylate (USAN);Nafamostat dimethanesulfonate;Nafamostat mesilate;Benzoic acid,4-[(aminoiminomethyl)amino]-,6- (aminoiminomethyl)-2-naphthalenyl ester,dimethanesulfonate;FUT 175;Futhan;[N-[4-[6-(azaniumylcarbonimidoyl)naphthalen-2-yl]oxycarbonylphenyl]carbamimidoyl]azanium; methanesulfonate;Nafamostat mesilate (JAN);Nafamostat mesylate [USAN];Ronastat (TN);Nafamostat Mesilate(CAS No: 82956-11-4);6-Amidino-2-naphthyl 4-guanidinobenzoate dimethanesulfonate; |
Article Data | 5 |
Nafamostat mesylate Chemical Properties
Molecular Structure:
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Molecular Formula: C21H25N5O8S2
Molecular Weight: 539.5819
IUPAC Name: (6-Carbamimidoylnaphthalen-2-yl) 4-(diaminomethylideneamino)benzoate; methanesulfonic acid
Synonyms of 6-Amidino-2-naphthyl 4-guanidinobenzoate dimethanesulfonate (CAS NO.82956-11-4): Nafamostat dimethanesulfonate ; Nafamostat mesylate [USAN] ; 6-Amidino-2-naphthyl p-guanidinobenzoate, dimethanesulfonate ; Benzoic acid, 4-((aminoiminomethyl)amino)-, 6-(aminoiminomethyl)-2-naphthalenyl ester, dimethanesulfonate ; FUT 175 ; Nafamostat mesilate ; Nafamostat mesylate
CAS NO: 82956-11-4
Classification Code: Anticoagulant ; Antifibrinolytic ; Antifibrinolytic agents ; Drug / Therapeutic Agent ; Reproductive Effect
Melting Point: 259-261°C
H bond acceptors: 7
H bond donors: 7
Freely Rotating Bonds: 5
Polar Surface Area: 54.26 Å2
Flash Point: 339.1 °C
Enthalpy of Vaporization: 94.13 kJ/mol
Boiling Point: 637.2 °C at 760 mmHg
Vapour Pressure: 3.9E-16 mmHg at 25°C
Nafamostat mesylate Uses
6-Amidino-2-naphthyl 4-guanidinobenzoate dimethanesulfonate (CAS NO.82956-11-4) is used as a non-peptide proteaseinhibitor.
Nafamostat mesylate Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| mammal (species unspecified) | LD50 | intraperitoneal | 200mg/kg (200mg/kg) | United States Patent Document. Vol. #4454338, | |
| mammal (species unspecified) | LD50 | oral | 2500mg/kg (2500mg/kg) | United States Patent Document. Vol. #4454338, | |
| mouse | LD50 | intraperitoneal | 269mg/kg (269mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 17, Pg. 1106, 1986. | |
| mouse | LD50 | intravenous | 24400ug/kg (24.4mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 17, Pg. 1106, 1986. | |
| mouse | LD50 | oral | 4600mg/kg (4600mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 17, Pg. 1106, 1986. | |
| mouse | LD50 | subcutaneous | 6180mg/kg (6180mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 17, Pg. 1106, 1986. | |
| rat | LD50 | intraperitoneal | 162mg/kg (162mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 17, Pg. 1106, 1986. | |
| rat | LD50 | intravenous | 16400ug/kg (16.4mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 17, Pg. 1106, 1986. | |
| rat | LD50 | oral | 3050mg/kg (3050mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 17, Pg. 1106, 1986. | |
| rat | LD50 | subcutaneous | 9200mg/kg (9200mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 17, Pg. 1106, 1986. |
Nafamostat mesylate Safety Profile
RTECS of 6-Amidino-2-naphthyl 4-guanidinobenzoate dimethanesulfonate (CAS NO.82956-11-4): DG2736000
A poison by intraperitoneal and intravenous routes. Moderately toxic by ingestion. Experimental reproductive effects. When heated to decomposition it emits toxic vapors of NOx and SOx.
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