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Name	Nimetazepam	EINECS	217-931-5
CAS No.	2011-67-8	Density	1.331 g/cm³
PSA	78.49000	LogP	2.43240
Solubility	N/A	Melting Point	-44 °C
Formula	C₁₆H₁₃N₃O₃	Boiling Point	540.467 °C at 760 mmHg
Molecular Weight	295.298	Flash Point	280.665 °C
Transport Information	N/A	Appearance	N/A
Safety	16-36/37-45	Risk Codes	11-23/24/25-39/23/24/25
Molecular Structure		Hazard Symbols	F,T
Synonyms	1-Methyl-5-phenyl-7-nitro-1,3-dihydro-2H-1,4-benzodiazepin-2-one;1-Methylnitrazepam;Elimin;Erimin;Hypnon;Methylnitrazepam;N-Methylmogadon;N-Methylnitrazepam;Nimetazam;Nimetazepam;Ro 5-3453;S 1530;2H-1,4-Benzodiazepin-2-one,1,3-dihydro-1-methyl-7-nitro-5-phenyl-;	Article Data	24

Nimetazepam Chemical Properties

Molecular Structure of Nimetazepam (CAS NO.2011-67-8):

IUPAC Name: 1-Methyl-7-nitro-5-phenyl-3H-1,4-benzodiazepin-2-one
Canonical SMILES: CN1C(=O)CN=C(C2=C1C=CC(=C2)[N+](=O)[O-])C3=CC=CC=C3
InChI: InChI=1S/C16H13N3O3/c1-18-14-8-7-12(19(21)22)9-13(14)16(17-10-15(18)20)11-5-3-2-4-6-11/h2-9H,10H2,1H3
InChIKey: GWUSZQUVEVMBPI-UHFFFAOYSA-N
Molecular Weight: 295.29272 [g/mol]
Molecular Formula: C₁₆H₁₃N₃O₃
XLogP3: 2.2
H-Bond Donor: 0
H-Bond Acceptor: 4
EINECS: 217-931-5
Melting Point: 156.5-7.5 °C
Index of Refraction: 1.66
Molar Refractivity: 81.97 cm³
Molar Volume: 221.9 cm³
Surface Tension: 55.3 dyne/cm
Density: 1.33 g/cm³
Flash Point: 280.7 °C
Enthalpy of Vaporization: 81.81 kJ/mol
Boiling Point: 540.5 °C at 760 mmHg
Vapour Pressure: 9.53E-12 mmHg at 25 °C
Water Solubility: 76.2 mg/L at 25 °C
Classification Code: Drug / Therapeutic Agent; Mutation data; Reproductive Effect; Tranquilizer

Nimetazepam Uses

Nimetazepam (CAS No.2011-67-8) is mainly used as antipsychotics.

Nimetazepam Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	intraperitoneal	510mg/kg (510mg/kg)	BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES	Oyo Yakuri. Pharmacometrics. Vol. 7, Pg. 705, 1973.
mouse	LD50	oral	750mg/kg (750mg/kg)	BEHAVIORAL: MUSCLE WEAKNESS LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION	Arzneimittel-Forschung. Drug Research. Vol. 22, Pg. 534, 1972.
mouse	LD50	subcutaneous	> 5gm/kg (5000mg/kg)	PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE) AUTONOMIC NERVOUS SYSTEM: "SMOOTH MUSCLE RELAXANT (MECHANISM UNDEFINED, SPASMOLYTIC)" BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)	Oyo Yakuri. Pharmacometrics. Vol. 7, Pg. 705, 1973.
rat	LD50	intraperitoneal	970mg/kg (970mg/kg)	BEHAVIORAL: MUSCLE WEAKNESS LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION	Arzneimittel-Forschung. Drug Research. Vol. 22, Pg. 534, 1972.
rat	LD50	oral	970mg/kg (970mg/kg)	BEHAVIORAL: MUSCLE WEAKNESS LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION	Arzneimittel-Forschung. Drug Research. Vol. 22, Pg. 534, 1972.
rat	LD50	subcutaneous	> 1gm/kg (1000mg/kg)	BEHAVIORAL: MUSCLE WEAKNESS LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES	Arzneimittel-Forschung. Drug Research. Vol. 22, Pg. 534, 1972.

Nimetazepam Safety Profile

Moderately toxic by ingestion and intraperitoneal routes. Experimental reproductive effects. An anticonvulsant and muscle relaxant. Related to diazepam. When heated to decomposition it emits toxic fumes of NO_x.

Nimetazepam Specification

Nimetazepam (CAS NO.2011-67-8), its Synonyms are 1-Methyl-5-phenyl-7-nitro-1,3-dihydro-2H-1,4-benzodiazepin-2-one ; 1-Methyl-7-nitro-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one ; 1-Methylnitrazepam ; Elimin ; Nimetazepam ; Nimetazepamum ; 2H-1,4-Benzodiazepin-2-one, 1,3-dihydro-1-methyl-7-nitro-5-phenyl- .