Hot Products

Basic Information

Post buying leads

Suppliers

Cas Database

Name	Nonivamide	EINECS	219-484-1
CAS No.	2444-46-4	Density	1.037 g/cm³
PSA	58.56000	LogP	4.15850
Solubility	methanol: 100 mg/mL, clear to slightly hazy	Melting Point	54 °C
Formula	C₁₇H₂₇NO₃	Boiling Point	492.7 °C at 760 mmHg
Molecular Weight	293.406	Flash Point	251.8 °C
Transport Information	UN 3462 6.1/PG 2	Appearance	solid
Safety	26-45-37/39	Risk Codes	25-36/37/38
Molecular Structure		Hazard Symbols	T,Xi
Synonyms	Nonanamide,N-vanillyl- (6CI,7CI,8CI);AH 23491X;N-Vanillylnonamide;NSC 172795;Nonanoylvanillyl amide;Vanillyl pelargonic amide;	Article Data	29

Nonivamide Synthetic route

: 1196-92-5
Vanillylamin

: 112-05-0
nonanoic acid

: 2444-46-4
Nonivamide

Conditions

Conditions	Yield
With 2-((N,N-diisopropylamino)methyl)-4-cyanophenylboronic acid In fluorobenzene at 85℃; for 3.5h; Reagent/catalyst; Solvent; Temperature; Molecular sieve; Green chemistry;	99%
With SiO2-H3BO3 In toluene for 7h; Reflux;	91%
With boric acid In toluene at 130℃; for 8h; Concentration; Temperature;	87.4%

: 764-85-2
Nonanoyl chloride

: 1196-92-5
Vanillylamin

: 2444-46-4
Nonivamide

Conditions

Conditions	Yield
Stage #1: Vanillylamin With sodium hydrogencarbonate In chloroform; water at 20℃; for 0.75h; Stage #2: Nonanoyl chloride In chloroform; water at 20 - 40℃; for 1h;	94%
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃;	88.6%
In diethyl ether; N,N-dimethyl-formamide Ambient temperature;	59%
With diethyl ether
With triethylamine

: 764-85-2
Nonanoyl chloride

: 7149-10-2
vanillylamine hydrochloride

: 2444-46-4
Nonivamide

Conditions

Conditions	Yield
With sodium hydrogencarbonate In dichloromethane; water at 20 - 42℃; for 2.5h; Temperature;	91.5%
Stage #1: vanillylamine hydrochloride With sodium hydroxide In water; N,N-dimethyl-formamide at 20℃; for 1h; Inert atmosphere; Cooling with ice; Stage #2: Nonanoyl chloride In tetrahydrofuran; water; N,N-dimethyl-formamide at 20℃; for 18h; Inert atmosphere; Cooling with ice;	60.51%

: 871570-36-4
3-methoxy-4-(triisopropylsilyloxy)-N-(nonanoyl)benzylamine

: 2444-46-4
Nonivamide

Conditions

Conditions	Yield
With tetrabutyl ammonium fluoride In tetrahydrofuran at 20℃; for 4h; Inert atmosphere;	84%
With tetrabutyl ammonium fluoride In tetrahydrofuran	81%

: 112-05-0
nonanoic acid

: 7149-10-2
vanillylamine hydrochloride

: 2444-46-4
Nonivamide

Conditions

Conditions	Yield
With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine In N,N-dimethyl-formamide at 0 - 20℃; Temperature;	81.1%

: 102811-97-2
N-(4-benzyloxy-3-methoxy-benzyl)-nonanamide

: 2444-46-4
Nonivamide

Conditions

Conditions	Yield
With palladium on activated charcoal; ethanol Hydrogenation;

: 90-05-1
2-methoxy-phenol

N-hydroxymethyl-nonamide: N-hydroxymethyl-nonamide

: 2444-46-4
Nonivamide

Conditions

Conditions	Yield
With hydrogenchloride

: 222622-85-7
3-methoxy-4-(triisopropylsilyloxy)benzonitrile

: 2444-46-4
Nonivamide

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: LiAlH4 / tetrahydrofuran / 20 °C 2: 4-DMAP; pyridine / CH2Cl2 / 0 - 20 °C 3: 81 percent / TBAF / tetrahydrofuran View Scheme

: 222620-67-9
3-methoxy-4-(triisopropylsilyloxy)-benzylamine

: 2444-46-4
Nonivamide

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 4-DMAP; pyridine / CH2Cl2 / 0 - 20 °C 2: 81 percent / TBAF / tetrahydrofuran View Scheme

: 4421-08-3
3-methoxy-4-hydroxybenzonitrile

: 2444-46-4
Nonivamide

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: 91 percent / imidazole / dimethylformamide / 20 °C 2: LiAlH4 / tetrahydrofuran / 20 °C 3: 4-DMAP; pyridine / CH2Cl2 / 0 - 20 °C 4: 81 percent / TBAF / tetrahydrofuran View Scheme

Nonivamide Chemical Properties

IUPAC Name:N-[(4-Hydroxy-3-methoxyphenyl)methyl]nonanamide
Molecular Formula:C₁₇H₂₇NO₃
Molecular Weight:293.401180 g/mol
Appearance:white to off-white powder
Melting Point:54°C
Boiling Point:492.7 °C at 760 mmHg
Flash Point:190°C
Density:1,1 g/cm³
Storage temp.:2-8°C
Methanol solubility:100 mg/mL, clear to slightly hazy
FEMA:2787
EINECS:219-484-1
Synonyms of Nonivamide (CAS NO.2444-46-4): N-((4-hydroxy-3-methoxyphenyl)methyl)-nonanamid ; N-[(4-hydroxy-3-methoxyphenyl)methyl]-nonanamid;Nonanoylvanilylamide ; Nonylicacidvanillylamide(nonivamide) ; Vanillyl-n-nonylamide ; Pseudocapsaicin ; Synthetic capsaicin ; Pelargonyl vanillylamide
Categories of Nonivamide(2444-46-4): INORGANIC & ORGANIC CHEMICALS ; Anilines, Aromatic Amines and Nitro Compounds

Nonivamide Uses

Nonivamide (CAS NO.2444-46-4) is used as a food additive to add pungency to seasonings, flavorings, and spice blends.
It is also used in confectionary industry to create hot sensation, and in the pharmaceutical industry in some formulations.
As a potent lachrymatory agent, Nonivamide (CAS NO.2444-46-4) is used as the active ingredient of some oleoresin capsicum-based riot control agents.

Nonivamide Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	intraperitoneal	8mg/kg (8mg/kg)		Journal of Medicinal Chemistry. Vol. 36, Pg. 2595, 1993.

Nonivamide Safety Profile

Hazard Codes Nonivamide (CAS NO.2444-46-4): Toxic T, Irritant Xi
Risk Statements: 25-36/37/38
R25: Toxic if swallowed.
R36/37/38: Irritating to eyes, respiratory system and skin.
Safety Statements: 26-45-37/39
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S45: In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S37/39: Wear suitable gloves and eye/face protection.
RIDADR: UN 3462 6.1/PG 2
WGK Germany: 3
RTECS: RA5998000
F: 19

Post a RFQ

Cas No.:

Product Name:

Quantity:

Email:

Company name:

Valid Period:

Detailed Requirements:

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

What can I do for you?
Get Best Price

Get Best Price for 2444-46-4