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| Name |
Noscapine hydrochloride |
EINECS | N/A |
| CAS No. | 912-60-7 | Density | 1.332g/cm3 |
| PSA | 75.69000 | LogP | 3.62170 |
| Solubility | N/A | Melting Point |
221-223 °C(lit.) |
| Formula | C22H23 N O7 . Cl H | Boiling Point | 565.3°Cat760mmHg |
| Molecular Weight | 449.888 | Flash Point | 295.7°C |
| Transport Information | N/A | Appearance | N/A |
| Safety | Poison by intravenous route. Moderately toxic by ingestion and subcutaneous routes. Mutation data reported. When heated to decomposition it emits very toxic fumes of HCl and NOx. | Risk Codes | 22 |
| Molecular Structure |
|
Hazard Symbols |
|
| Synonyms |
1(3H)-Isobenzofuranone,6,7-dimethoxy-3-(5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl)-,hydrochloride, [S-(R*,S*)]-; 1(3H)-Isobenzofuranone,6,7-dimethoxy-3-[(5R)-5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]-,hydrochloride, (3S)- (9CI); Narcotine, hydrochloride (7CI,8CI);1,3-Dioxolo[4,5-g]isoquinoline, 1(3H)-isobenzofuranone deriv.; Noscapinehydrochloride; Opianine hydrochloride; l-Narcotine hydrochloride |
Noscapine hydrochloride Chemical Properties
IUPAC Name: (3S)-6,7-Dimethoxy-3-[(5R)-4-methoxy-6-methyl-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinolin-6-ium-5-yl]-3H-isobenzofuran-1-one chloride
Synonyms: 1(3H)-Isobenzofuranone, 6,7-dimethoxy-3-[(5R)-5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]-, (3S)-, hydrochloride (1:1) ; Coscopin hydrochloride ; Methoxyhydrastine hydrochloride ; Narcompren hydrochloride
CAS NO:912-60-7
Molecular Formula of Noscapine hydrochloride (CAS NO.912-60-7) :C22H24ClNO7
Molecular Weight of Noscapine hydrochloride (CAS NO.912-60-7) :449.88
Molecular Structure of Noscapine hydrochloride (CAS NO.912-60-7) :.png)
EINECS: 213-014-9
Flash Point: 295.7 °C
Enthalpy of Vaporization: 84.91 kJ/mol
Boiling Point: 565.3 °C at 760 mmHg
Vapour Pressure: 8.42E-13 mmHg at 25°C
Melting point: 221-223 °C(lit.)
Storage temp: 2-8°C
Noscapine hydrochloride Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| dog | LD50 | intravenous | 52mg/kg (52mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA KIDNEY, URETER, AND BLADDER: URINE VOLUME INCREASED | Journal of Pharmacology and Experimental Therapeutics. Vol. 123, Pg. 287, 1958. |
| guinea pig | LDLo | intravenous | 83mg/kg (83mg/kg) | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 119, Pg. 205, 1959. | |
| mouse | LD50 | intraperitoneal | 581mg/kg (581mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: ATAXIA | Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 57, Pg. 538, 1961. |
| mouse | LD50 | oral | 853mg/kg (853mg/kg) | Yakugaku Zasshi. Journal of Pharmacy. Vol. 81, Pg. 266, 1961. | |
| mouse | LD50 | subcutaneous | 700mg/kg (700mg/kg) | United States Patent Document. Vol. #3031377 |
Noscapine hydrochloride Safety Profile
Poison by intravenous route. Moderately toxic by ingestion and subcutaneous routes. Mutation data reported. When heated to decomposition it emits very toxic fumes of HCl and NOx.
Hazard Codes 
Xn,Xi
Risk Statements 22
R22:Harmful if swallowed.
Safety Statements 36
S36:Wear suitable protective clothing.
RIDADR 1544
WGK Germany 3
RTECS NP7225000
F 10
HazardClass 6.1(b)
PackingGroup III