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| Name |
Pepleomycin sulfate |
EINECS | 274-588-4 |
| CAS No. | 70384-29-1 | Density | N/A |
| PSA | 778.56000 | LogP | 0.31600 |
| Solubility | N/A | Melting Point |
196-198°C |
| Formula | C61H90N18O25S3 | Boiling Point | N/A |
| Molecular Weight | 1571.67 | Flash Point | N/A |
| Transport Information | N/A | Appearance | N/A |
| Safety | Poison by intraperitoneal, subcutaneous, and intravenous routes. Questionable carcinogen with experimental carcinogenic data. An eye irritant. When heated to decomposition it emits very toxic fumes of NOx and SOx. | Risk Codes | N/A |
| Molecular Structure |
|
Hazard Symbols | N/A |
| Synonyms |
NK 631;Peplomycin sulfate;Bleomycinamide,N1-[3-[[(1S)-1-phenylethyl]- amino]propyl]-,sulfate (1:1) (salt);Peplomycin sulfate (JP14/USAN);Pepleo (TN);Pepleo; |
Pepleomycin sulfate Chemical Properties
IUPAC Name: [2-[2-[2-[[6-Amino-2-[3-amino-1-[(2,3-diamino-3-oxopropyl)amino]-3-oxopropyl]-5-methylpyrimidine-4-carbonyl]amino]-3-[[3-hydroxy-5-[[3-hydroxy-1-oxo-1-[2-[4-[4-[3-(1-phenylethylamino)propylcarbamoyl]-
1,3-thiazol-2-yl]-1,3-thiazol-2-yl]ethylamino]butan-2-yl]amino]-4-methyl-5-oxopentan-2-yl]amino]-1-(1H-
imidazol-5-yl)-3-oxopropoxy]-4,5-dihydroxy-6-(hydroxymethyl)oxan-3-yl]oxy-3,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl] carbamate; sulfuric acid
Synonyms of Pepleomycin sulfate (CAS NO.70384-29-1) : N1-[3-[(1-Phenylethyl)amino]propyl]bleomycinamide Sulfate (1:1) (Salt) ; N1-[3-[[(S)-a-Methylbenzyl]amino]propyl]bleomycinamide Sulfate (1:1) (Salt) ; Pepleo ; Pepleomycin sulfate ; Peplomycin sulfate ; Peplomycin sulfate salt
Product Categories: Chiral Reagents;Intermediates & Fine Chemicals;Pharmaceuticals
CAS NO:70384-29-1
Molecular Formula:C61H90N18O25S3
Molecular Weight :1571.6679
Molecular Structure :
EINECS: 274-588-4
Flash Point: 1064.4 °C
Enthalpy of Vaporization: 311.88 kJ/mol
Boiling Point: 1836.4 °C at 760 mmHg
Vapour Pressure: 0 mmHg at 25°C
Melting Point: 196-198°C
Appearance: Pepleomycin sulfate (CAS NO.70384-29-1) is pale yellow amorphous powder .
Pepleomycin sulfate Uses
Pepleomycin sulfate (CAS NO.70384-29-1) is a derivative of Bleomycin with cytostatic activity and less pulmonary toxicity than the natural Bleomycin mixture.
Pepleomycin sulfate Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| dog | LD | intravenous | > 50mg/kg (50mg/kg) | LIVER: "HEPATITIS (HEPATOCELLULAR NECROSIS), DIFFUSE" KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)" GASTROINTESTINAL: OTHER CHANGES | Japanese Journal of Antibiotics. Vol. 31, Pg. 719, 1978. |
| mouse | LD50 | intraperitoneal | 77mg/kg (77mg/kg) | Japanese Journal of Antibiotics. Vol. 31, Pg. 719, 1978. | |
| mouse | LD50 | intravenous | 45mg/kg (45mg/kg) | Japanese Journal of Antibiotics. Vol. 31, Pg. 719, 1978. | |
| mouse | LD50 | oral | > 1gm/kg (1000mg/kg) | Drugs in Japan Vol. 6, Pg. 762, 1982. | |
| mouse | LD50 | subcutaneous | 80mg/kg (80mg/kg) | Japanese Journal of Antibiotics. Vol. 31, Pg. 719, 1978. | |
| mouse | LDLo | intratracheal | 1572ng/kg (0.001572mg/kg) | LUNGS, THORAX, OR RESPIRATION: FIBROSIS (INTERSTITIAL) | Toxicology and Applied Pharmacology. Vol. 56, Pg. 326, 1980. |
| rat | LD50 | intraperitoneal | 155mg/kg (155mg/kg) | "Bleomycin: Current Status and New Development, Papers Presented in a Symposium, Oakland, CA, 1977," Carter, S.K., et al., eds., New York, Academic Press, Inc., 1978Vol. -, Pg. 311, 1978. | |
| rat | LD50 | intravenous | 215mg/kg (215mg/kg) | Japanese Journal of Antibiotics. Vol. 31, Pg. 719, 1978. | |
| rat | LD50 | oral | > 2gm/kg (2000mg/kg) | Drugs in Japan Vol. 6, Pg. 762, 1982. | |
| rat | LD50 | subcutaneous | 199mg/kg (199mg/kg) | Japanese Journal of Antibiotics. Vol. 31, Pg. 719, 1978. |
Pepleomycin sulfate Safety Profile
Poison by intraperitoneal, subcutaneous, and intravenous routes. Questionable carcinogen with experimental carcinogenic data. An eye irritant. When heated to decomposition it emits very toxic fumes of NOx and SOx.
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