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Pheniodol

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Name

Pheniodol

EINECS N/A
CAS No. 577-91-3 Density 2.081g/cm3
PSA 57.53000 LogP 4.01230
Solubility N/A Melting Point 164°C
Formula C15H12I2O3 Boiling Point 439°C at 760 mmHg
Molecular Weight 494.067 Flash Point 219.3°C
Transport Information N/A Appearance N/A
Safety Poison by intravenous route. Moderately toxic by ingestion, intraperitoneal, and subcutaneous routes. When heated to decomposition it emits very toxic fumes of I. Risk Codes N/A
Molecular Structure Molecular Structure of 577-91-3 (Pheniodol) Hazard Symbols N/A
Synonyms

Biliselectan;2-Phenyl-3-(3,5-dijod-4-hydroxy-phenyl)-propionsaeure;Biliselktan;Jodobil;3-(4-Hydroxy-3,5-dijod-phenyl)-2-phenyl-propionsaeure;3-(4-Hydroxy-3,5-diiodo-phenyl)-2-phenyl-propanoic acid;Pheniodol;Biselectan;3-(4-hydroxy-3,5-diiodo-phenyl)-2-phenyl-propionic acid;Coletrast;Bilitrast;Biliognost;3-(3.5-Dijod-4-hydroxy-phenyl)-2-phenyl-propionsaeure;Benzenepropanoic acid, 4-hydroxy-3,5-diiodo-α-phenyl-;Iodoalphionic acid;Iodobil;

 

Pheniodol Chemical Properties

IUPAC Name: 3-(4-Hydroxy-3,5-diiodophenyl)-2-phenylpropanoic acid
Synonyms of Pheniodol (CAS NO.577-91-3) : 3-(4-Hydroxy-3,5-diiodophenyl)-2-phenylpropanoic acid ; 3,5-Diiodo-a-phenylphloretic Acid ; 4-Hydroxy-3,5-diiodo-a-phenylbenzenepropanoic Acid ; b-(4-Hydroxy-3,5-diiodophenyl)-a-phenylpropionic Acid ; Benzenepropanoic acid, 4-hydroxy-3,5-diiodo-alpha-phenyl-
CAS NO: 577-91-3
Molecular Formula:C15H12I2O3
Molecular Weight :494.0629
Molecular Structure :
Index of Refraction: 1.724
Surface Tension: 68.2 dyne/cm
Density: 2.081 g/cm3
Flash Point: 219.3 °C
Enthalpy of Vaporization: 73.34 kJ/mol
Boiling Point: 439 °C at 760 mmHg
Vapour Pressure: 1.76E-08 mmHg at 25°C 
Appearance: Pheniodol (CAS NO.577-91-3) is white or milky white crystalline powder with slightly smelly, and irritating odor.
Solubility: Insoluble in water, soluble in ethanol or ether, slightly soluble in chloroform, soluble in alkaline aqueous solution.

Pheniodol Uses

 Pheniodol (CAS NO.577-91-3) is used as oral cholecystography agents.

Pheniodol Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
cat LDLo intravenous 100mg/kg (100mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Journal of Laboratory and Clinical Medicine. Vol. 27, Pg. 1376, 1942.
cat LDLo oral 500mg/kg (500mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: FOOD INTAKE (ANIMAL)

GASTROINTESTINAL: NAUSEA OR VOMITING
Journal of Laboratory and Clinical Medicine. Vol. 27, Pg. 1376, 1942.
guinea pig LD50 intraperitoneal 930mg/kg (930mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: ANTIPSYCHOTIC

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 42, Pg. 476, 1953.
mouse LD50 intraperitoneal 640mg/kg (640mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: ANTIPSYCHOTIC

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 42, Pg. 476, 1953.
mouse LD50 intravenous 400mg/kg (400mg/kg)   Journal of Medicinal Chemistry. Vol. 13, Pg. 997, 1970.
mouse LD50 oral 2950mg/kg (2950mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: ANTIPSYCHOTIC

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 42, Pg. 476, 1953.
rat LD50 intraperitoneal 510mg/kg (510mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: ANTIPSYCHOTIC

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 42, Pg. 476, 1953.
rat LD50 intravenous 390mg/kg (390mg/kg) BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)

LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Klinische Wochenscrift. Vol. 20, Pg. 125, 1941.
rat LD50 oral 1100mg/kg (1100mg/kg) BEHAVIORAL: MUSCLE WEAKNESS

BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)
Klinische Wochenscrift. Vol. 20, Pg. 125, 1941.
rat LD50 subcutaneous 540mg/kg (540mg/kg) BEHAVIORAL: MUSCLE WEAKNESS

BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)
Klinische Wochenscrift. Vol. 20, Pg. 125, 1941.

Pheniodol Safety Profile

Poison by intravenous route. Moderately toxic by ingestion, intraperitoneal, and subcutaneous routes. When Pheniodol (CAS NO.577-91-3) is heated to decomposition, it emits very toxic fumes of I.

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