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Name	Polyoxin B	EINECS	243-024-9
CAS No.	19396-06-6	Density	1.774 g/cm³
PSA	309.98000	LogP	-4.84660
Solubility	N/A	Melting Point	150-153 °C (decomp)
Formula	C₁₇H₂₅N₅O₁₃	Boiling Point	595.71°C (rough estimate)
Molecular Weight	507.411	Flash Point	N/A
Transport Information	N/A	Appearance	N/A
Safety		Risk Codes	N/A
Molecular Structure		Hazard Symbols	N/A
Synonyms	Allofuranuronicacid,5-(2-amino-2-deoxy-L-xylonamido)-1,5-dideoxy-1-[3,4-dihydro-5-(hydroxymethyl)-2,4-dioxo-1(2H)-pyrimidinyl]-,monocarbamate (ester), b-D- (8CI);Polyoxin B (7CI);Milpan;Polar;Polar (antibiotic);	Article Data	1

Polyoxin B Chemical Properties

IUPAC Name: (2S)-2-[[(2S,3S,4S)-2-Amino-5-carbamoyloxy-3,4-dihydroxypentanoyl]amino]-2-[(2R,3S,4R,5R)-3,4-dihydroxy-5-[5-(hydroxymethyl)-
2,4-dioxopyrimidin-1-yl]oxolan-2-yl]acetic acid
Synonyms: Polyoxin B ; 5-(2-Amino-5-o-carbamoyl-2-deoxy-l-xylonamido-1,5-dideoxy-1-(3,4-dihydro-5-hydroxymethyl-2,4-dioxo-1-(2h)-pyrimidinyl)-beta-d-allofuranuronicacid ; 5-[[2-Amino-5-o-(aminocarbonyl)-2-deoxy-l-xylonoyl]amino]-1,5-dideoxy-1-[3,4-dihydro-5-(hydroxymeth.beta.-d-Allofuranuronicacid ; Allofuranuronicacid,5-(2-amino-2-deoxy-l-xylonamido)-1,5-dideoxy-1-(3,4-dihyd;polyoxinal ; Ro-5-(hydroxymethyl)-2,4-dioxo-1(2H)-pyrimidinyl)-,monocarbamate(ester),bet ; Piomycin ; Polyoxin AL(JMAF)
CAS NO: 19396-06-6
Molecular Formula: C₁₇H₂₅N₅O₁₃
Molecular Weight: 507.41
Molecular Structure:
EINECS: 243-024-9
Mol File: 19396-06-6.mol
Index of Refraction: 1.669 Surface Tension: 112.1 dyne/cm Density: 1.774 g/cm3
Storage temp: 0-6°C
Melting point:180 °C
Appearance: Polyoxin AL (CAS NO.19396-06-6) is colorless needle crystal.
Solubility: Polyoxin AL (CAS NO.19396-06-6) is soluble in water, insoluble in methanol, ethanol, acetone, chloroform, benzene and ether and other organic solvents.
Stability:Polyoxin AL (CAS NO.19396-06-6) is stable to the ultraviolet light, acid solution, neutral solution, , instability in alkaline solution

Polyoxin B Uses

Polyoxin AL (CAS NO.19396-06-6) is broad-spectrum antibiotics, fungicides, with absorption and conduction. Its mechanism is to interfere with cell wall chitin biosynthesis. and is mainly used for prevention and control of wheat powdery mildew, black spot ginseng, tobacco brown spot disease, downy mildew of cucumber, melon fusarium wilt, rice sheath blight, Alternaria leaf disease, strawberry and grape Botrytis cinerea, tree diseases such as multiple dry sheath kinds of fungus diseases.

Polyoxin B Production

Slope of sand control bacteria strains [10 ~ 14d, 26 °C ] → shake-flask seed [36 ~ 48h, 28 °C ] → Seed pot seeds [24h, 28 °C ] → fermentation [90 ~ 120h, 28°C ] put cans , fermentation broth acidified (pH = 3 ~ 4) → concentrated → drying → packing

Polyoxin B Toxicity Data With Reference

1.	orl-rat LD50:14,665 mg/kg	FMCHA2 Farm Chemicals Handbook .(Meister Publishing,Willoughy, OH.: )1983,C192.
2.	orl-mus LD50:15,638 mg/kg	FMCHA2 Farm Chemicals Handbook .(Meister Publishing,Willoughy, OH.: )1983,C192.
3.	ivn-mus LD50:200 mg/kg	85DGAU Catalog of Teratogenic Agents. 5 (1981),245.

Polyoxin B Safety Profile

Poison by intravenous route. Mildly toxic by ingestion. When heated to decomposition it emits toxic fumes of NO_x. See also CARBAMATES.

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