Dibenzo[b,d]furan-3-carbonitrile

Base Information

• Chemical Name: Dibenzo[b,d]furan-3-carbonitrile
• CAS No.: 29021-90-7
• Molecular Formula: C₁₃H₇NO
• Molecular Weight: 193.205
• Hs Code.: 2932999099
• Mol file: 29021-90-7.mol

Synonyms:Dibenzo[b,d]furan-3-carbonitrile;3-Dibenzofurancarbonitrile;

Chemical Property of Dibenzo[b,d]furan-3-carbonitrile

Chemical Property:

• PSA: 36.93000
• LogP: 3.45768
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

Dibenzo[b,d]furan-3-carbonitrile 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Dibenzo[b,d]furan-3-carbonitrile

There total 15 articles about Dibenzo[b,d]furan-3-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

4-iodo-3-phenoxybenzonitrile → dibenzo[b,d]furan-3-carbonitrile (29021-90-7)

Guidance literature:

With palladium 10% on activated carbon; sodium acetate; In N,N-dimethyl acetamide; at 140 ℃; for 16h;

DOI:10.1021/acs.joc.5b00634

Reference yield: 85.0%

zinc(II) cyanide (557-21-1) + 3-iododibenzo[b,d]furan (5896-29-7) → dibenzo[b,d]furan-3-carbonitrile (29021-90-7)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; In N,N-dimethyl-formamide; at 90 ℃; for 2h; Inert atmosphere;

DOI:10.1016/j.bmc.2016.09.041

Reference yield: 85.0%

3-iododibenzo[b,d]furan (5896-29-7) + dicyanozinc (557-21-1) → dibenzo[b,d]furan-3-carbonitrile (29021-90-7)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; In N,N-dimethyl-formamide; at 90 ℃; for 2h; Inert atmosphere;

upstream raw materials:

dibenzofuran

bromocyane

cyanogen iodide

sodium cyanide

Downstream raw materials:

dibenzo[b,d]furan-3-carboxylic acid

1-dibenzofuran-3-yl-ethanone-(2,4-dinitro-phenylhydrazone)

4-dibenzofuran-3-yl-butyric acid

Refernces

• 1、 Zhu, Daqian,Li, Min,Wu, Zhouming,Du, Yongliang,Luo, Bingling,Huang, Peng,Wen, Shijun. "Copper-Catalyzed One-Pot Synthesis of Dibenzofurans, Xanthenes, and Xanthones from Cyclic Diphenyl Iodoniums". supporting information. p. 4566 - 4571. Retrieved 2019/07/09.
• 2、 Xu, Zhixiang,Xu, Xiangxiang,O'Laoi, Ruadhan,Ma, Haikuo,Zheng, Jiyue,Chen, Shuaishuai,Luo, Lusong,Hu, Zhilin,He, Sudan,Li, Jiajun,Zhang, Hongjian,Zhang, Xiaohu. "Design, synthesis, and evaluation of novel porcupine inhibitors featuring a fused 3-ring system based on the ‘reversed’ amide scaffold". . p. 5861 - 5872. Retrieved 2016/10/30.