2-CHLORO-4,5-DIFLUOROBENZAMIDE

Base Information

• Chemical Name: 2-CHLORO-4,5-DIFLUOROBENZAMIDE
• CAS No.: 296274-32-3
• Molecular Formula: C7H4ClF2NO
• Molecular Weight: 191.56300
• Hs Code.: 2924299090
• Mol file: 296274-32-3.mol

Synonyms:1-acetyl-2-chloro-4,5-difluorobenzene;Ethanone,1-(2-chloro-4,5-difluorophenyl);2-CHLORO-4,5-DIFLUOROACETOPHENONE;

Chemical Property of 2-CHLORO-4,5-DIFLUOROBENZAMIDE

Chemical Property:

• Boiling Point: 201.5±40.0 °C(Predicted)
• PKA: 14.74±0.50(Predicted)
• PSA: 44.08000
• Density: 1.490±0.06 g/cm3(Predicted)
• LogP: 2.60130

Purity/Quality:

99% ^*data from raw suppliers

2-Chloro-4,5-difluorobenzamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-CHLORO-4,5-DIFLUOROBENZAMIDE

There total 1 articles about 2-CHLORO-4,5-DIFLUOROBENZAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

2-chloro-4,5-difluorobenzoic acid (110877-64-0) → 2-chloro-4,5-difluorobenzamide (296274-32-3)

Guidance literature:

2-chloro-4,5-difluorobenzoic acid; With 1-hydroxy-pyrrolidine-2,5-dione; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 1h;

With ammonia; In water; N,N-dimethyl-formamide; at 0 - 20 ℃; for 0.5h;

Reference yield:

2-chloro-4,5-difluorobenzamide (296274-32-3) + oxalyl dichloride (79-37-8) → 2-chloro-4,5-difluorobenzoyl isocyanate (634616-77-6)

Guidance literature:

In 1,2-dichloro-ethane; for 21h; Heating;

DOI:10.1021/jm049034y

Reference yield:

2-chloro-4,5-difluorobenzamide (296274-32-3) → 1-(5-amino-2-methoxyphenyl)-3-(2-chloro-4,5-difluorobenzoyl)urea (648927-52-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 1,2-dichloro-ethane / 21 h / Heating

2: 97 percent / 1-methyl-pyrrolidin-2-one / 1 h

3: 69 percent / SnCl₂*H₂O / ethyl acetate / 1 h / 70 °C

With tin(ll) chloride; In 1-methyl-pyrrolidin-2-one; ethyl acetate; 1,2-dichloro-ethane;

DOI:10.1021/jm049034y

upstream raw materials:

2-chloro-4,5-difluorobenzoic acid

Downstream raw materials:

2-chloro-4,5-difluorobenzoyl isocyanate

1-(5-amino-2-chlorophenyl)-3-(2-chloro-4,5-difluorobenzoyl)urea

1-(2-chloro-5-nitrophenyl)-3-(2-chloro-4,5-difluorobenzoyl)urea

1-(2-chloro-4,5-difluorophenyl)-3-(2-methoxy-5-nitrobenzoyl)urea

Refernces

• 1、 -. "Acylcarboxylic-4-Carboxyamino phenylureas deriv., its manufacture and its use". Page/Page column 28. . Retrieved 2008/06/13.