Cyclobutane-1-one oxime

Base Information

• Chemical Name: Cyclobutane-1-one oxime
• CAS No.: 2972-05-6
• Molecular Formula: C4H7NO
• Molecular Weight: 85.1057
• Hs Code.: 2928000090
• Mol file: 2972-05-6.mol

Synonyms:cyclobutanonoxime;Cyclobutanone,oxime;cyclobutan-1-one oxime;Cyclobutanon-oxim;N-Hydroxycyclobutanimine;

Chemical Property of Cyclobutane-1-one oxime

Chemical Property:

• Melting Point: 81-82 °C
• Boiling Point: 173.4±9.0 °C(Predicted)
• PKA: 12.42±0.20(Predicted)
• PSA: 32.59000
• Density: 1.22±0.1 g/cm3(Predicted)
• LogP: 1.00050

Purity/Quality:

95% ^*data from raw suppliers

Cyclobutaneoxime 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Cyclobutane-1-one oxime

There total 3 articles about Cyclobutane-1-one oxime which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

cyclobutanone (1191-95-3) → cyclobutanone oxime (2972-05-6)

Guidance literature:

With hydroxylamine hydrochloride; sodium carbonate; In water; at 40 ℃; pH=7 - 8;

Reference yield:

cyclobutane (287-23-0) → cyclobutanone oxime (2972-05-6)

Guidance literature:

With tert.-butylnitrite; at 0 - 5 ℃; Irradiation;

Reference yield:

→ cyclobutanone oxime (2972-05-6)

Guidance literature:

upstream raw materials:

cyclobutanone

cyclobutane

Downstream raw materials:

nitrocyclobutane

1-bromo-1-nitrocyclobutane

2-pyrrolidinon

Refernces

• 1、 Olive,Le Moigne,Mercier,Rockenbauer,Tordo. "Synthesis of tetraalkyl (pyrrolidine-2,2-diyl)bisphosphonates and 2,2- bis(diethoxyphosphoryl)-3,4-dihydro-2H-pyrrole 1-oxide; ESR study of derived nitroxides". . p. 9095 - 9099. Retrieved 1998.
• 2、 Ding, Ling,Liu, Yuxiu,Niu, Kaikai,Wang, Qingmin. "Electro-reductive C-H cyanoalkylation of quinoxalin-2(1H)-ones". supporting information. . Retrieved 2022/01/24.
• 3、 Shuai, Bin,Fang, Ping,Mei, Tian-Sheng. "Nickel-Catalyzed Favorskii-Type Rearrangement of Cyclobutanone Oxime Esters to Cyclopropanecarbonitriles". supporting information. p. 1637 - 1641. Retrieved 2021/10/02.