3-METHYL-1,2,3,4-TETRAHYDROISOQUINOLINE

Base Information

• Chemical Name: 3-METHYL-1,2,3,4-TETRAHYDROISOQUINOLINE
• CAS No.: 29726-60-1
• Molecular Formula: C10H13N
• Molecular Weight: 147.22
• Hs Code.: 2933499090
• Mol file: 29726-60-1.mol

Synonyms:

Chemical Property of 3-METHYL-1,2,3,4-TETRAHYDROISOQUINOLINE

Chemical Property:

• Vapor Pressure: 0.0381mmHg at 25°C
• PSA: 12.03000
• LogP: 2.04960
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

98%,99%, ^*data from raw suppliers

3-Methyl-1,2,3,4-tetrahydroisoquinoline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-METHYL-1,2,3,4-TETRAHYDROISOQUINOLINE

There total 26 articles about 3-METHYL-1,2,3,4-TETRAHYDROISOQUINOLINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.1%

3-methylisoquinoline (1125-80-0) → 3-Methyl-1,2,3,4-tetrahydroisoquinoline (29726-60-1)

Guidance literature:

With sodium tetrahydroborate; nickel dichloride; In methanol; Ambient temperature;

Reference yield: 96.0%

3-methylisoquinoline hydrochloride (54304-65-3) → 3-(S)-methyl-1,2,3,4-tetrahydroisoquinoline (15547-43-0,29726-60-1)

Guidance literature:

With chloro(1,5-cyclooctadiene)rhodium(I) dimer; ZhaoPhos; hydrogen; In dichloromethane; isopropyl alcohol; at 25 ℃; for 24h; under 30402 Torr; Reagent/catalyst; Temperature; Solvent; enantioselective reaction; Catalytic behavior;

DOI:10.1039/c5sc04712a

Reference yield: 87.0%

(2-allylphenyl)methanamine (59816-88-5) → 3-Methyl-1,2,3,4-tetrahydroisoquinoline (29726-60-1)

Guidance literature:

With bis(acetonitrile)(1,5-cyclooctadiene)rhodium(I) tetrafluoroborate; 2,7-di-tert-butyl-4,5-bis[bis(diethylamino)phosphonito]-9,9-dimethylxanthene; In tert-butyl alcohol; at 70 ℃; for 5h; Inert atmosphere;

DOI:10.1021/ja1052126

upstream raw materials:

3-methylisoquinoline

acetone enolate ion

2-iodobenzylamine

acetone

Refernces

• 1、 Wen, Jialin,Tan, Renchang,Liu, Shaodong,Zhao, Qingyang,Zhang, Xumu. "Strong Br?nsted acid promoted asymmetric hydrogenation of isoquinolines and quinolines catalyzed by a Rh-thiourea chiral phosphine complex: Via anion binding". . p. 3047 - 3051. Retrieved 2016/05/19.
• 2、 Wu, Jianjun,Wang, Chao,Tang, Weijun,Pettman, Alan,Xiao, Jianliang. "The remarkable effect of a simple ion: Iodide-promoted transfer hydrogenation of heteroaromatics". supporting information; experimental part. p. 9525 - 9529. Retrieved 2012/08/28.