((3-FLUOROPHENYL)METHYLENE)METHANE-1,1-DICARBONITRILE

Base Information

• Chemical Name: ((3-FLUOROPHENYL)METHYLENE)METHANE-1,1-DICARBONITRILE
• CAS No.: 2972-71-6
• Molecular Formula: C10H5FN2
• Molecular Weight: 172.162
• Hs Code.: 2926909090
• Mol file: 2972-71-6.mol

Synonyms:3-Fluorobenzylidenemalononitrile;(3-fluorobenzylidene)propanedinitrile;3-Fluorbenzylidenmalonitril;2-(3-fluorophenyl)-1,1-dicyanovinyl;2-(3-fluoro-benzylidene)-malononitrile;

Chemical Property of ((3-FLUOROPHENYL)METHYLENE)METHANE-1,1-DICARBONITRILE

Chemical Property:

• PSA: 47.58000
• LogP: 2.25626

Purity/Quality:

95% ^*data from raw suppliers

2-[(3-fluorophenyl)methylene]malononitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ((3-FLUOROPHENYL)METHYLENE)METHANE-1,1-DICARBONITRILE

There total 5 articles about ((3-FLUOROPHENYL)METHYLENE)METHANE-1,1-DICARBONITRILE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

malononitrile (109-77-3) + 3-Fluorobenzaldehyde (456-48-4) → 3-fluorobenzylidenemalononitrile (2972-71-6)

Guidance literature:

With C₇H₄O₅S^(2-)*C₁₆H₁₆N₄O₂*3H₂O*Zn⁽²⁺⁾; In N,N-dimethyl-formamide; at 35 ℃; for 0.5h;

DOI:10.1039/c8nj02055h

Reference yield:

2-[Butylsulfanyl-(3-fluoro-phenyl)-methyl]-malononitrile → n-butanethiol (109-79-5) + 3-fluorobenzylidenemalononitrile (2972-71-6)

Guidance literature:

at 25 ℃; Equilibrium constant;

DOI:10.1139/v68-128

Reference yield:

3-fluoro-benzenemethanol (456-47-3) + malononitrile (109-77-3) → 3-fluorobenzylidenemalononitrile (2972-71-6)

Guidance literature:

With oxygen; In toluene; at 100 ℃; for 15h; under 760.051 Torr;

DOI:10.1002/ejic.201500808

upstream raw materials:

malononitrile

3-Fluorobenzaldehyde

3-fluoro-benzenemethanol

Downstream raw materials:

7‐amino‐5‐(3‐fluorophenyl)‐6-cyano‐5H‐pyrano[2,3‐d]pyrimidin‐(1H,3H)-2,4‐dione

4-(3-Fluoro-phenyl)-6-methyl-2-thioxo-1,2-dihydro-pyridine-3-carbonitrile

6-Amino-4-(3-fluoro-phenyl)-2,2-dimethyl-4H-[1,3]dithiine-5-carbonitrile

2-amino-4-(3-fluorophenyl)-3-cyano-4H-naphtho<2,1-b>pyran

Refernces

• 1、 Akhmadiev, Nail S.,Akhmetova, Vnira R.,Ibragimov, Askhat G.,Mescheryakova, Ekaterina S.. "Metal-free multicomponent synthesis of novel macrocyclic tetrathiadienes with cyano and amino groups". . p. 18768 - 18775. Retrieved 2021/06/03.
• 2、 Liu, Min,Zhou, Leijie,Shi, Wangyu,Hu, Yimin,Liao, Jianning,Duan, Zeqing,Wang, Wei,Wu, Yongjun,Zheng, Bing,Guo, Hongchao. "Phosphine-Catalyzed (4 + 2) Annulation of δ-Sulfonamido-Substituted Enones with 1,1-Dicyanoalkenes: Synthesis of Piperidine Derivatives". supporting information. p. 7703 - 7707. Retrieved 2021/10/20.