O-Benzyl-N,N'-diisopropylisourea

Base Information

• Chemical Name: O-Benzyl-N,N'-diisopropylisourea
• CAS No.: 2978-10-1
• Molecular Formula: C14H22N2O
• Molecular Weight: 234.341
• Mol file: 2978-10-1.mol

Synonyms:N,N'-diisopropyl-0-benzyl-isourea;O-benzyl-N,N-diisopropylurea;2-benzyl-1,3-diisopropyl isourea;1,3-diisopropyl-2-benzylisourea;O-Benzyl-N,N'-diisopropylisourea;N,N'-diisopropyl-o-benzylisourea;

Chemical Property of O-Benzyl-N,N'-diisopropylisourea

Chemical Property:

• Refractive Index: 1.4980-1.5020
• Boiling Point: 105°C/1.1mmHg(lit.)
• PKA: 9.46±0.50(Predicted)
• PSA: 33.62000
• Density: 0.96±0.1 g/cm3(Predicted)
• LogP: 3.35650

Purity/Quality:

98%,99%, ^*data from raw suppliers

O-Benzyl-N,N'-diisopropylisourea >97.0%(GC)(T) ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of O-Benzyl-N,N'-diisopropylisourea

There total 3 articles about O-Benzyl-N,N'-diisopropylisourea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

diisopropyl-carbodiimide (693-13-0) + benzyl alcohol (100-51-6,185532-71-2) → O-benzyl-N,N'-diisopropylisourea (2978-10-1)

Guidance literature:

With copper(l) chloride; at 0 - 20 ℃;

DOI:10.1016/j.tet.2009.05.051

Reference yield: 85.0%

diisopropyl-carbodiimide (693-13-0) + benzyl alcohol (100-51-6,185532-71-2) → N,N'-diisopropyl-O-benzyl isourea (2978-10-1,113282-06-7)

Guidance literature:

With C₃₂H₄₄N₆P₂Se₂Ti₂; In toluene; at 25 ℃; for 3h; Concentration; Temperature; chemoselective reaction; Kinetics; Glovebox; Schlenk technique;

DOI:10.1021/acs.inorgchem.8b01766

Reference yield:

→ O-benzyl-N,N'-diisopropylisourea (2978-10-1)

Guidance literature:

Benzylalkohol, N,N'-Di-iso-propylcarbodiimid;

DOI:10.1021/ma60063a022

upstream raw materials:

diisopropyl-carbodiimide

benzyl alcohol

Downstream raw materials:

Benzyl 4-hydroxybenzoate

DL-phenylalanine benzyl ester

2-benzylthiobenzothiazole

2-(benzylthio)benzo[d]oxazole

Refernces

• 1、 -. "Synthetic method for isourea catalyzed by rare-earth compound". Paragraph 0038; 0039; 0046; 0047; 0056-0079. . Retrieved 2018/03/24.
• 2、 Pícha, Jan,Budě?ínsky, Milo?,Han?lová, Ivona,?anda, Miloslav,Fiedler, Pavel,Vaněk, Václav,Jirá?ek, Ji?í. "Efficient synthesis of phosphonodepsipeptides derived from norleucine". experimental part. p. 6090 - 6103. Retrieved 2011/03/18.