Cbz-Gly-Gly-OEt

Base Information

• Chemical Name: Cbz-Gly-Gly-OEt
• CAS No.: 3005-87-6
• Molecular Formula: C14H18N2O5
• Molecular Weight: 294.307
• Hs Code.: 2924299090
• Mol file: 3005-87-6.mol

Synonyms:Cbz-Gly-Gly-OEt;N-benzyloxycarbonylglycylglycine ethyl ester;Glycine, N-[N-[(phenylmethoxy)carbonyl]glycyl]-, ethyl ester;ZGlyGlyOEt;Z-Gly-GlyOEt;Z-glycylglycine ethyl ester;Cbz-glycylglycine ethyl ester;

Chemical Property of Cbz-Gly-Gly-OEt

Chemical Property:

• PSA: 93.73000
• LogP: 1.37390

Purity/Quality:

95% ^*data from raw suppliers

Z-GLYCYL GLYCINE ETHYL ESTER 98.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Technology Process of Cbz-Gly-Gly-OEt

There total 39 articles about Cbz-Gly-Gly-OEt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

glycine ethyl ester hydrochloride (623-33-6) + Benzyloxycarbonylamino-acetic acid 1-methylene-pentyl ester (137862-14-7) → Z-Gly-Gly-OEt (3005-87-6)

Guidance literature:

With triethylamine; potassium cyanide; In ethyl acetate; at 20 - 25 ℃; for 6h;

DOI:10.1016/S0040-4039(00)92385-2

Reference yield: 95.0%

C24H23N3O4 + GlyOEt*HCl (459-73-4) → Z-Gly-Gly-OEt (3005-87-6) + N'-methyl-N'-phenylbenzohydrazide (52023-39-9)

Guidance literature:

In water; acetone; pH 7.8;

DOI:10.1021/ja00533a049

Reference yield: 94.0%

N-allyl-sinnamic acid amide + N-benzyloxycarbonyl-glycine pyrimidine-2-yl thiolester + glycine ethyl ester hydrochloride (623-33-6) → Z-Gly-Gly-OEt (3005-87-6)

Guidance literature:

With triethylamine; In ethyl acetate;

upstream raw materials:

N-(Benzyloxycarbonyl)glycine

GlyOEt*HCl

Glycine ethyl ester isocyanate

o-phenylene chlorophosphate

Downstream raw materials:

CbzGlyGly

Cbz-glycylglycyl hydrazide

Z-glycylglycinamide

Z-Gly-ψ(CSNH)-Gly-OEt

Refernces

• 1、 Cortes-Clerget, Margery,Berthon, Jean-Yves,Krolikiewicz-Renimel, Isabelle,Chaisemartin, Laurent,Lipshutz, Bruce H.. "Tandem deprotection/coupling for peptide synthesis in water at room temperature". supporting information. p. 4263 - 4267. Retrieved 2017/09/28.
• 2、 Nowshuddin, Shaik,Ram Reddy. "Synthesis of dipeptides from N-hydroxy-3-azaspiro[5,5]undecane-2,4-dione activated α-amino acids". . p. 22 - 25. Retrieved 2011/04/18.