Phosphine oxide, bis(2-methylphenyl)-

Base Information

• Chemical Name: Phosphine oxide, bis(2-methylphenyl)-
• CAS No.: 30309-80-9
• Molecular Formula: C14H15OP
• Molecular Weight: 230.246
• Mol file: 30309-80-9.mol

Synonyms:

Chemical Property of Phosphine oxide, bis(2-methylphenyl)-

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Phosphine oxide, bis(2-methylphenyl)-

There total 14 articles about Phosphine oxide, bis(2-methylphenyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

2-methylchlorobenzene (95-49-8) → di-o-tolylphosphine oxide (30309-80-9)

Guidance literature:

2-methylchlorobenzene; With magnesium; In tetrahydrofuran; at 20 ℃; for 4h; Inert atmosphere; Schlenk technique;

With phosphonic acid diethyl ester; In tetrahydrofuran; at 20 ℃; for 2.25h; Inert atmosphere; Schlenk technique; Cooling with ice;

DOI:10.1021/ja509381w

Reference yield: 91.0%

bis(o-tolyl)chlorophosphine (36042-94-1) → di-o-tolylphosphine oxide (30309-80-9)

Guidance literature:

With water; Inert atmosphere; Schlenk technique;

DOI:10.1002/chem.201701414

Reference yield: 88.0%

2-methylphenyl bromide (95-46-5) → di-o-tolylphosphine oxide (30309-80-9)

Guidance literature:

2-methylphenyl bromide; With magnesium; In tetrahydrofuran; at 20 ℃; for 2h;

With phosphonic acid diethyl ester; In tetrahydrofuran;

DOI:10.1021/acs.orglett.9b00569

upstream raw materials:

ortho-tolylmagnesium bromide

2-methylphenyl bromide

phosphonic acid diethyl ester

Diethyl phosphonate

Downstream raw materials:

(2-(pyridin-2-yl)phenyl)di-o-tolylphosphine oxide

tetra(o-tolyl)diphosphane

1,1,2-tris(di(o-tolyl)phosphoryl)ethane

C₃₅H₄₀O₄P₂

Refernces

• 1、 Zhang, Song,Feng, Zhenghuai,Jiang, Chunhui,Yu, Xiaojun,Pan, Jianke,Du, Juan,Jiang, Zhiyu,Chen, Yuan,Wang, Tianli. "Highly Enantioselective Synthesis of Phosphorus-Containing ?-Benzosultams by Bifunctional Phosphonium Salt-Promoted Hydrophosphonylation". supporting information. p. 11285 - 11290. Retrieved 2021/07/02.
• 2、 Kang, Qi-Kai,Li, Yuntong,Lin, Yunzhi,Shi, Hang. "Ru(II)-Catalyzed Amination of Aryl Fluorides via η6-Coordination". supporting information. p. 3706 - 3711. Retrieved 2020/03/11.