Technology Process of Benzeneacetic acid, a-fluoro-a-phenyl-, methyl ester
There total 5 articles about Benzeneacetic acid, a-fluoro-a-phenyl-, methyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
carbon dioxide; difluorodiphenylmethane;
With
triethylsilane; 1,3-dicyano-5-fluoro-2,4,6-tris(diphenylamino)benzene; caesium carbonate;
In
dimethyl sulfoxide;
at 25 - 30 ℃;
for 8h;
under 760.051 Torr;
Inert atmosphere;
Schlenk technique;
Sealed tube;
Irradiation;
methyl iodide;
With
potassium carbonate;
In
acetone;
at 70 ℃;
for 4h;
Overall yield = 43.7 mg;
Inert atmosphere;
Schlenk technique;
DOI:10.1016/j.chempr.2021.08.004
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: (bis-(2-methoxyethyl)amino)sulfur trufluoride / 36 h / 90 °C / Inert atmosphere; Schlenk technique
2.1: caesium carbonate; triethylsilane; 1,3-dicyano-5-fluoro-2,4,6-tris(diphenylamino)benzene / dimethyl sulfoxide / 8 h / 25 - 30 °C / 760.05 Torr / Inert atmosphere; Schlenk technique; Sealed tube; Irradiation
2.2: 4 h / 70 °C / Inert atmosphere; Schlenk technique
With
triethylsilane; 1,3-dicyano-5-fluoro-2,4,6-tris(diphenylamino)benzene; caesium carbonate; (bis-(2-methoxyethyl)amino)sulfur trufluoride;
In
dimethyl sulfoxide;
DOI:10.1016/j.chempr.2021.08.004
- Guidance literature:
-
With
n-butyllithium; p-tolylSO2NF(exo-2-norbornyl);
Yield given. Multistep reaction;
1.) PhCH3, THF, -50 deg C;
DOI:10.1021/ja00314a050
