Piperidine, 1-(4-methylphenyl)-

Base Information

• Chemical Name: Piperidine, 1-(4-methylphenyl)-
• CAS No.: 31053-03-9
• Molecular Formula: C12H17N
• Molecular Weight: 175.274
• Mol file: 31053-03-9.mol

Synonyms:1-p-tolylpiperidine;N-(4-tolyl)piperidine;1-p-Tolyl-piperidine;1-(p-tolyl)piperidine;N-(p-methylphenyl)piperidine;1-(4-methylphenyl)piperidine;N-(4-methylphenyl)-piperidine;

Chemical Property of Piperidine, 1-(4-methylphenyl)-

Chemical Property:

• Melting Point: 264 - 266 °C
• PSA: 3.24000
• LogP: 3.05030

Purity/Quality:

98%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Piperidine, 1-(4-methylphenyl)-

There total 47 articles about Piperidine, 1-(4-methylphenyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

piperidine (110-89-4) + para-chlorotoluene (106-43-4) → N-(4-methylphenyl)piperidine (31053-03-9)

Guidance literature:

With (N,N'-diarylimidazol-2-ylidene)-based palladacycle; sodium t-butanolate; In 1,4-dioxane; at 70 ℃; for 0.5h;

DOI:10.1021/ol034264c

Reference yield: 98.0%

piperidine (110-89-4) + para-bromotoluene (106-38-7) → N-(4-methylphenyl)piperidine (31053-03-9)

Guidance literature:

With lithium hexamethyldisilazane; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; 1,3-bis[(2,6-diisopropyl)phenyl]imidazolinium chloride; In tetrahydrofuran; at 22 ℃; for 10h;

DOI:10.1016/j.jorganchem.2005.07.084

Reference yield: 97.0%

1,5-dibromo-pentane (111-24-0) + p-toluidine (106-49-0,12221-03-3) → N-(4-methylphenyl)piperidine (31053-03-9)

Guidance literature:

With potassium carbonate; sodium iodide; In acetonitrile; for 40h; Reflux;

DOI:10.1002/ejoc.202001510

upstream raw materials:

TETRAHYDROPYRANE

p-toluidine

piperidine

para-bromotoluene

Downstream raw materials:

2,2,2-trifluoro-1-<5-methyl-2-(1-piperidinyl)phenyl>ethanone

2,2,2-trifluoro-1-<5-methyl-2-(1-pyrrolidinyl)phenyl>-1,1-ethanediol

(5-bromo-pentyl)-p-tolyl-carbamonitrile

Refernces

• 1、 Mauger, Christelle,Buisine, Olivier,Caravieilhes, Sylvain,Mignani, Gérard. "Successful application of microstructured continuous reactor in the palladium catalysed aromatic amination". . p. 3627 - 3629. Retrieved 2005.
• 2、 Rong, Xiaona,Guo, Jingwen,Hu, Zheqi,Huang, Lehao,Gu, Yugui,Cai, Yuepiao,Liang, Guang,Xia, Qinqin. "Iodine-Mediated Coupling of Cyclic Amines with Sulfonyl Hydrazides: an Efficient Synthesis of Vinyl Sulfone Derivatives". supporting information. p. 701 - 708. Retrieved 2020/12/30.
• 3、 Mudithanapelli, Chandrashekar,Kim, Mi-Hyun. "Metal-free late-stage C(sp2)-H functionalization of: N -aryl amines with various sodium salts". . p. 450 - 464. Retrieved 2020/02/03.