2H-Pyrido[1,2-a]pyrimidine-2,4(3H)-dione

Base Information

• Chemical Name: 2H-Pyrido[1,2-a]pyrimidine-2,4(3H)-dione
• CAS No.: 22288-66-0
• Molecular Formula: C8H6N2O2
• Molecular Weight: 162.148
• Hs Code.: 2933990090
• Mol file: 22288-66-0.mol

Synonyms:4-Oxopyrido[1,2-a]pyrimidin-1-ium-2-olate;NSC 93435;

Chemical Property of 2H-Pyrido[1,2-a]pyrimidine-2,4(3H)-dione

Chemical Property:

• Vapor Pressure: 0.00158mmHg at 25°C
• Melting Point: 305 °C (decomp)
• Refractive Index: 1.676
• Boiling Point: 294.9 °C at 760 mmHg
• PKA: 9.43±0.20(Predicted)
• Flash Point: 132.1 °C
• PSA: 51.43000
• Density: 1.41g/cm³
• LogP: -0.60510

Purity/Quality:

98%min ^*data from raw suppliers

2H-Pyrido[1,2-a]pyrimidine-2,4(3H)-dione 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2H-Pyrido[1,2-a]pyrimidine-2,4(3H)-dione is used as a reactant in the nitration of 4-?hydroxy-?3-?nitro-?2-?quinolones and related compounds as inhibitors of allergic reactions.

Technology Process of 2H-Pyrido[1,2-a]pyrimidine-2,4(3H)-dione

There total 5 articles about 2H-Pyrido[1,2-a]pyrimidine-2,4(3H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

2-aminopyridine (504-29-0) + malonic acid bis-(2,4,6-trichloro-phenyl) ester (15781-70-1) → 2H,3H,4H-pyrido[1,2-a]pyrimidine-2,4-dione (22288-66-0)

Guidance literature:

In acetone; Heating;

DOI:10.1016/S0040-4020(01)87057-5

Reference yield: 96.0%

2-aminopyridine (504-29-0) + diethyl malonate (105-53-3) → 2H,3H,4H-pyrido[1,2-a]pyrimidine-2,4-dione (22288-66-0)

Guidance literature:

In ethanol; at 160 - 180 ℃;

DOI:10.1016/S0040-4020(01)87057-5

Reference yield:

2-aminopyridine (504-29-0) + malonic acid (141-82-2) → 2H,3H,4H-pyrido[1,2-a]pyrimidine-2,4-dione (22288-66-0)

Guidance literature:

2-aminopyridine; malonic acid; for 1h; Heating; neat (no solvent);

With phosphorus pentoxide; In N,N-dimethyl-formamide; at 150 - 160 ℃;

DOI:10.1002/jhet.465

upstream raw materials:

2-aminopyridine

malonic acid

malonoyl dichloride

diethyl malonate

Downstream raw materials:

pyrido[1,2-a]pyrimidine-2,3,4-trione-3-phenylhydrazone

2-chloro-4H-pyrido[1,2-a]pyrimidin-4-one

14,15-dihydro-13H-14-(3,4-dimethoxyphenyl)dipyrido[1,2-a:1',2'-a']thiopyrano[2,3-d:6,5-d']dipyrimidine-13,15-dione

14,15-dihydro-13H-14-(3,4-dimethoxyphenyl)dipyrido[1,2-a:1',2'-a']pyrano[2,3-d:6,5-d']dipyrimidine-13,15-dione

Refernces

• 1、 Gupta, Poonam,Gupta, Shallu,Sachar, Anand,Sharma. "Synthesis of novel and biologically potent heteropolycyclics containing bridge head nitrogen". experimental part. p. 1188 - 1199. Retrieved 2010/11/16.
• 2、 Dunn, Allan D.,Norrie, Robert. "A Novel in situ Cycloaddition Reaction". . p. 98 - 99. Retrieved 2007/10/02.