N-Methyl-N-benzylcarbamic acid ethyl ester

Base Information

• Chemical Name: N-Methyl-N-benzylcarbamic acid ethyl ester
• CAS No.: 59325-17-6
• Molecular Formula: C11H15NO2
• Molecular Weight: 193.246
• Mol file: 59325-17-6.mol

Synonyms:Benzyl-methyl-carbamidsaeure-aethylester;N-methyl benzyl urethane;

Chemical Property of N-Methyl-N-benzylcarbamic acid ethyl ester

Chemical Property:

• Vapor Pressure: 0.00363mmHg at 25°C
• Boiling Point: 281.1°C at 760 mmHg
• PKA: -1.31±0.70(Predicted)
• Flash Point: 123.8°C
• PSA: 29.54000
• Density: 1.058g/cm³
• LogP: 2.27490

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-Methyl-N-benzylcarbamic acid ethyl ester

There total 10 articles about N-Methyl-N-benzylcarbamic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

carbon dioxide (124-38-9,18923-20-1) + ethyl iodide (75-03-6) + benzyl-methyl-amine (103-67-3) → ethyl benzyl(methyl)carbamate (59325-17-6)

Guidance literature:

benzyl-methyl-amine; With tetraethylammonium perchlorate; In acetonitrile; at 20 ℃; Electrochemical reaction; divided cells, Pt anode;

carbon dioxide; In acetonitrile; at 20 ℃; for 1h;

ethyl iodide; In acetonitrile; at 20 ℃; Further stages.;

DOI:10.1021/jo0266036

Reference yield: 90.0%

carbon dioxide (124-38-9,18923-20-1) + ethyl iodide (75-03-6) + N-methylaniline (100-61-8) → ethyl benzyl(methyl)carbamate (59325-17-6)

Guidance literature:

With caesium carbonate; In dimethyl sulfoxide; chemoselective reaction;

DOI:10.1002/cssc.201600521

Reference yield: 88.0%

carbonic acid ethyl ester-isopropenyl ester (63436-79-3) + benzyl-methyl-amine (103-67-3) → ethyl benzyl(methyl)carbamate (59325-17-6)

Guidance literature:

at 65 ℃; for 48h;

DOI:10.1021/jo01310a057

upstream raw materials:

Ethyl N-methylcarbamate

benzyl chloride

ethyl N-benzylcarbamate

methyl iodide

Downstream raw materials:

2-methyl-3-phenyl-2,3-dihydro-1H-isoindol-1-one

3-(4-chlorophenyl)-2-methylisoindolin-1-one

3-hydroxy-2-methyl-3-phenyl-2,3-dihydro-isoindol-1-one

Refernces

• 1、 Riemer, Daniel,Hirapara, Pradipbhai,Das, Shoubhik. "Chemoselective synthesis of carbamates using CO2 as carbon source". . p. 1916 - 1920. Retrieved 2018/08/17.
• 2、 Feroci, Marta,Casadei, Maria Antonietta,Orsini, Monica,Palombi, Laura,Inesi, Achille. "Cyanomethyl anion/carbon dioxide system: An electrogenerated carboxylating reagent. Synthesis of carbamates under mild and safe conditions". . p. 1548 - 1551. Retrieved 2007/10/03.