Technology Process of 1H-1-Benzazepine-4-carboxylic acid,
7-[4-(2-butoxyethoxy)phenyl]-2,3-dihydro-1-propyl-
There total 17 articles about 1H-1-Benzazepine-4-carboxylic acid,
7-[4-(2-butoxyethoxy)phenyl]-2,3-dihydro-1-propyl- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
water; sodium hydroxide;
In
tetrahydrofuran; methanol;
for 3h;
Reflux;
DOI:10.1021/op0497916
- Guidance literature:
-
Multi-step reaction with 6 steps
1: sodium hydroxide; water / 8 h / Reflux
2: sodium carbonate / water; dimethyl sulfoxide / 4 h / Reflux
3: potassium carbonate / N,N-dimethyl-formamide / 1 h / 25 - 40 °C
4: sodium methylate / N,N-dimethyl-formamide; methanol / 0.5 h / 50 °C
5: palladium diacetate; triphenylphosphine; potassium phosphate / tetrahydrofuran / 5.5 h / 20 °C / Reflux; Inert atmosphere
6: sodium hydroxide; water / methanol; tetrahydrofuran / 3 h / Reflux
With
potassium phosphate; water; sodium methylate; palladium diacetate; sodium carbonate; potassium carbonate; triphenylphosphine; sodium hydroxide;
In
tetrahydrofuran; methanol; water; dimethyl sulfoxide; N,N-dimethyl-formamide;
4: |Claisen Condensation / 5: |Suzuki-Miyaura Coupling;
DOI:10.1021/op0497916
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: sodium acetate; bromine / water; acetic acid / 0.5 h / 10 - 20 °C
2.1: tetra(n-butyl)ammonium hydrogensulfate; sodium hydroxide / water; dimethyl sulfoxide / 1.5 h / 35 - 40 °C
3.1: magnesium / tetrahydrofuran / 1.5 h / Inert atmosphere; Reflux
3.2: 0.5 h / -10 °C / Inert atmosphere
4.1: palladium diacetate; triphenylphosphine; potassium phosphate / tetrahydrofuran / 4 h / Reflux; Inert atmosphere
With
potassium phosphate; bromine; sodium acetate; tetra(n-butyl)ammonium hydrogensulfate; palladium diacetate; magnesium; triphenylphosphine; sodium hydroxide;
In
tetrahydrofuran; water; acetic acid; dimethyl sulfoxide;
4.1: |Suzuki-Miyaura Coupling;
DOI:10.1021/op0497916
![methyl 7-[4-(2-butoxyethoxy)phenyl]-1-propyl-2,3-dihydro-1H-1-benzazepine-4-carboxylate](/Databaselist/images/loading.webp)
