2-ethylquinazolin-4-ol

Base Information

• Chemical Name: 2-ethylquinazolin-4-ol
• CAS No.: 3137-64-2
• Molecular Formula: C10H10N2O
• Molecular Weight: 174.202
• Hs Code.: 2933990090
• Mol file: 3137-64-2.mol

Synonyms:Ethyl 3-(trifluoromethyl)-1H-pyrazole-4-carboxylate;Ethyl 3-(trifluoromethyl)pyrazole-4-carboxylate;2-ethyl-3,4-dihydro-4-quinazolinone;2-ethyl-4-oxo-3,4-dihydroquinazoline;2-Ethylquinazolin-4(1H)-one;ethyl-3,4-dihydroquinazolin-4-one;2-ethyl-3H-quinazolin-4-one;2-ethylquinazolin-3H-4-one;3-trifluoromethyl-1H-pyrazol-4-carboxylic acid ethyl ester;3-(trifluoromethyl)pyrazole-4-carboxylic acid ethyl ester;2-ethyl-4(3H)-quinazolinone;3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid ethyl ester;

Chemical Property of 2-ethylquinazolin-4-ol

Chemical Property:

• Vapor Pressure: 0.000391mmHg at 25°C
• Melting Point: 236-237℃
• Boiling Point: 317.2oC at 760 mmHg
• Flash Point: 145.6oC
• PSA: 45.75000
• Density: 1.22g/cm3
• LogP: 1.48550
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

2-Ethyl-3H-quinazolin-4-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-ethylquinazolin-4-ol

There total 94 articles about 2-ethylquinazolin-4-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

isatoic anhydride (118-48-9) + Triethyl orthopropionate (115-80-0) → 2-ethyl-3H-quinazolin-4-one (3137-64-2)

Guidance literature:

With aluminum potassium sulfate dodecahydrate; ammonium acetate; for 0.116667h; Microwave irradiation; neat (no solvent);

DOI:10.1002/cjoc.201180344

Reference yield: 95.0%

anthranilic acid amide (28144-70-9,88-68-6) + 3,5-heptanedione (7424-54-6) → 2-ethyl-3H-quinazolin-4-one (3137-64-2)

Guidance literature:

With phosphoric acid; In ethanol; at 50 ℃; for 15h; Schlenk technique; Inert atmosphere;

DOI:10.1021/acs.joc.5b00937

Reference yield: 94.0%

anthranilic acid amide (28144-70-9,88-68-6) + Triethyl orthopropionate (115-80-0) → 2-ethyl-3H-quinazolin-4-one (3137-64-2)

Guidance literature:

With antimony(III) chloride; In neat (no solvent); for 0.05h; Microwave irradiation; Green chemistry;

upstream raw materials:

2-ethylquinazoline

2-ethyl-benzo[d][1,3]oxazin-4-one

N-propionyl-anthranilonitrile

anthranilic acid

Downstream raw materials:

2-Isopropyl-3H-quinazolin-4-one

4-chloro-2-ethylquinazoline

2-acetyl-4(3H)-quinazolidinone

Refernces

• 1、 Ulukanli, Sabri,Karabuga, Semistan,Celik, Ayhan,Kazaz, Cavit. "Substrate-controlled diastereoselective aziridination of alkenes using 3-acetoxyaminoquinazolinone in the presence of hexamethyldisilazane". . p. 197 - 199. Retrieved 2005.
• 2、 Atkinson, Robert S.,Darrah, Christine M.,Kelly, Brian J.. "AZIRIDINATION OF ALKENES BY 3-AMINO-2-ETHYLQUINAZOLIN-3H-4-ONE AND LEAD TETRA-ACETATE-TRIFLUOROACETIC ACID". . p. 1711 - 1712. Retrieved 1987.
• 3、 Xie, Zongbo,Lan, Jin,Zhu, Haibo,Lei, Gaoyi,Jiang, Guofang,Le, Zhanggao. "Visible light induced tandem reactions: An efficient one pot strategy for constructing quinazolinones using in-situ formed aldehydes under photocatalyst-free and room-temperature conditions". supporting information. p. 1427 - 1431. Retrieved 2020/11/02.
• 4、 Prinsloo, Izak F.,Zuma, Nonkululeko H.,Aucamp, Janine,N’Da, David D.. "Synthesis and in vitro antileishmanial efficacy of novel quinazolinone derivatives". . p. 383 - 398. Retrieved 2020/09/23.