2-{2-[2-(2-Hydroxyphenoxy)ethoxy]ethoxy}phenol

Base Information

• Chemical Name: 2-{2-[2-(2-Hydroxyphenoxy)ethoxy]ethoxy}phenol
• CAS No.: 23116-94-1
• Molecular Formula: C16H18 O5
• Molecular Weight: 290.316
• Hs Code.: 2909500000
• European Community (EC) Number: 878-381-5
• NSC Number: 175880
• DSSTox Substance ID: DTXSID30306360
• Nikkaji Number: J31.975I
• Wikidata: Q82053423
• Mol file: 23116-94-1.mol

Synonyms:23116-94-1;2-{2-[2-(2-hydroxyphenoxy)ethoxy]ethoxy}phenol;2-[2-[2-(2-hydroxyphenoxy)ethoxy]ethoxy]phenol;1,5-BIS(O-HYDROXYPHENOXY)-3-OXAPENTANE;Phenol, 2,2'-[oxybis(2,1-ethanediyloxy)]bis-;2,2'-((Oxybis(ethane-2,1-diyl))bis(oxy))diphenol;NSC175880;SBB059257;1,5-Bis[2'-Hydroxyphenoxy]-3-oxapentan;SCHEMBL11184862;DTXSID30306360;2,2'-(Oxydiethylenedioxy)-diphenol;Bis(2(2-hydroxyphenoxy)ethyl)-ether;MFCD00068542;STK391777;bis[2-(o-hydroxyphenoxy)ethyl] ether;[-2-(2-hydroxyphenoxy)-ethyl]-ether;AKOS001579618;NSC-175880;2,2'-(3-Oxapentamethylenedioxy)diphenol;NCGC00335902-01;1,5-Bis(2-hydroxyphenoxy)-3-oxapentane;Phenol, 2-(2-(2-hydroxyphenoxy)ethoxy);2,2'-[Oxybis(2,1-ethanediyloxy)]diphenol;2,2'-[oxybis(ethane-2,1-diyloxy)]diphenol;B5207;CS-0450161;FT-0727793;F87236;AB00275080-03;2-(2-[2-(2-Hydroxyphenoxy)ethoxy]ethoxy)phenol #;Phenol, 2-[2-[2-(2-hydroxyphenoxy)ethoxy]ethoxy]-;Z56763306;2,2'-(2,2'-oxybis(ethane-2,1-diyl)bis(oxy))diphenol

Chemical Property of 2-{2-[2-(2-Hydroxyphenoxy)ethoxy]ethoxy}phenol

Chemical Property:

• Boiling Point: 477.2oC at 760 mmHg
• Flash Point: 242.4oC
• PSA: 68.15000
• Density: 1.237g/cm3
• LogP: 2.57220
• XLogP3: 2.3
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 8
• Exact Mass: 290.11542367
• Heavy Atom Count: 21
• Complexity: 247

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C(=C1)O)OCCOCCOC2=CC=CC=C2O

Technology Process of 2-{2-[2-(2-Hydroxyphenoxy)ethoxy]ethoxy}phenol

There total 13 articles about 2-{2-[2-(2-Hydroxyphenoxy)ethoxy]ethoxy}phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2,2'-((oxybis(ethane-2,1-diyl))bis(oxy))bis((benzyloxy)benzene) (86955-49-9) → bis(2-hydroxyphenoxyethyl)ether (23116-94-1)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In ethyl acetate; at 20 ℃; for 2h; under 1500.15 Torr; Inert atmosphere;

DOI:10.3998/ark.5550190.p008.981

Reference yield: 97.0%

2,2'-<3-oxapentane-1,5-diylbis(oxy)diyl>dianisole (66224-00-8) → bis(2-hydroxyphenoxyethyl)ether (23116-94-1)

Guidance literature:

With trimethylsilyl iodide; In chloroform; for 12h; Ambient temperature;

Reference yield: 68.0%

1,5-bis(benzaldehydeoxy)-3-oxopentane (82645-24-7) → bis(2-hydroxyphenoxyethyl)ether (23116-94-1)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 25 ℃; for 2h;

DOI:10.5012/jkcs.2014.58.2.193

upstream raw materials:

dibenzo-18-crown-6

fluorene radical anion

2,2'-((oxybis(ethane-2,1-diyl))bis(oxy))bis((benzyloxy)benzene)

benzene-1,2-diol

Downstream raw materials:

sym-hydroxyphenyldibenzo-16-crown-5

17-Benzyloxymethyl-6,7,9,10,17,18-hexahydro-5,8,11,16,19-pentaoxa-dibenzo[a,g]cyclopentadecene

20-Benzyloxymethyl-2,5,8,15,18,21,24-heptaoxa-tricyclo[23.4.0.0^9,14]nonacosa-1⁽²⁹⁾,9⁽¹⁴⁾,10,12,25,27-hexaene

1,5-di[2-(2'-carboxydecyloxy)phenoxy]-3-oxapentane

Refernces

• 1、 Gaiser, Birgit I.,Danielsen, Mia,Marcher-R?rsted, Emil,R?pke J?rgensen, Kira,Wróbel, Tomasz M.,Frykman, Mikael,Johansson, Henrik,Br?uner-Osborne, Hans,Gloriam, David E.,Mathiesen, Jesper Mosolff,Sejer Pedersen, Daniel. "Probing the Existence of a Metastable Binding Site at the β2-Adrenergic Receptor with Homobivalent Bitopic Ligands". . p. 7806 - 7839. Retrieved 2019/09/07.
• 2、 Moradgholi, Fatemeh,Vahedi, Hooshang,Lari, Jalil. "Highly efficient synthesis of tetra benzo spiro bis-crown ether". . p. 85 - 90. Retrieved 2015/06/23.