(R)-Piperidin-2-ylmethanol

Base Information

• Chemical Name: (R)-Piperidin-2-ylmethanol
• CAS No.: 3197-44-2
• Molecular Formula: C6H13NO
• Molecular Weight: 115.175
• Hs Code.: 2933399990
• European Community (EC) Number: 818-908-8
• Nikkaji Number: J768.548C
• Mol file: 3197-44-2.mol

Synonyms:(R)-Piperidin-2-ylmethanol;3197-44-2;((R)-PIPERIDIN-2-YL)METHANOL;(2R)-piperidin-2-ylmethanol;[(2R)-piperidin-2-yl]methanol;2-Piperidinemethanol, (2R)-;(R)-2-HYDROXYMETHYLPIPERIDINE;(2R)-2-Piperidinemethanol;(r)-piperidine-2-ylmethanol;MFCD11036292;(R)-2-Piperidinemethanol;SCHEMBL1872941;PRAYXGYYVXRDDW-ZCFIWIBFSA-N;(2R)-Piperidin-2-ylmethanol: 95%;AKOS015856167;CS-W018567;AS-20061;EN300-115908;Z1203731003

Chemical Property of (R)-Piperidin-2-ylmethanol

Chemical Property:

• Vapor Pressure: 0.0225mmHg at 25°C
• Boiling Point: 98-102 °C(Press: 1.0 Torr)
• PKA: 15.08±0.10(Predicted)
• PSA: 32.26000
• Density: 0.951±0.06 g/cm3(Predicted)
• LogP: 0.44960
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• XLogP3: 0
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 115.099714038
• Heavy Atom Count: 8
• Complexity: 65.5

Purity/Quality:

98%, ^*data from raw suppliers

((R)-Piperidin-2-yl)methanol 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CCNC(C1)CO
• Isomeric SMILES: C1CCN[C@H](C1)CO

Technology Process of (R)-Piperidin-2-ylmethanol

There total 28 articles about (R)-Piperidin-2-ylmethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

benzyl (R)-2-(hydroxymethyl)piperidine-1-carboxylate (154499-13-5) → (2R)-piperidin-2-ylmethanol (3197-44-2)

Guidance literature:

With hydrogen; palladium on activated charcoal;

DOI:10.1016/j.bmcl.2004.10.094

Reference yield: 100.0%

tert-butyl (2R)-2-(hydroxymethyl)piperidine-1-carboxylate (134441-61-5) → (2R)-piperidin-2-ylmethanol (3197-44-2)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h;

Reference yield: 97.0%

(R)-(1-tosylpiperidin-2-yl)methanol (60343-64-8) → (2R)-piperidin-2-ylmethanol (3197-44-2)

Guidance literature:

With naphthalene; sodium; In tetrahydrofuran; at -78 ℃; for 2h; Inert atmosphere;

DOI:10.1002/anie.201904833

upstream raw materials:

(+)-2R-Piperidine-2-carboxylic acid methyl ester

ethyl acetate

piperidin-2-ylmethanol

(R)-(+)-pipecolic acid

Downstream raw materials:

tert-butyl (2R)-2-(hydroxymethyl)piperidine-1-carboxylate

(R)-2-hydroxymethyl-1-(2-iodobenzoyl)piperidine

Refernces

• 1、 Berthold, Dino,Geissler, Arne G. A.,Giofré, Sabrina,Breit, Bernhard. "Rhodium-Catalyzed Asymmetric Intramolecular Hydroamination of Allenes". supporting information. p. 9994 - 9997. Retrieved 2019/07/04.
• 2、 -. "QUINAZOLINE DERIVATIVES". Page/Page column 12-13. . Retrieved 2010/07/08.