4-Amino-1-naphthoic acid

Base Information

• Chemical Name: 4-Amino-1-naphthoic acid
• CAS No.: 32018-87-4
• Molecular Formula: C11H9NO2
• Molecular Weight: 187.198
• Hs Code.: 2922499990
• Mol file: 32018-87-4.mol

Synonyms:4-Amino-1-naphthoic acid;1-Naphthalenecarboxylic acid, 4-amino-;4-amino-1-naphthalenecarboxylic acid;

Chemical Property of 4-Amino-1-naphthoic acid

Chemical Property:

• Melting Point: 176 °C
• Boiling Point: 438.0±28.0 °C(Predicted)
• PKA: 4.73±0.10(Predicted)
• PSA: 63.32000
• Density: 1.352±0.06 g/cm3(Predicted)
• LogP: 2.70140
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

98%,99%, ^*data from raw suppliers

4-Amino-1-naphthoicacid 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Amino-1-naphthoic acid

There total 1 articles about 4-Amino-1-naphthoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-nitro-1-naphthoic acid (1975-43-5) → 4-Amino-1-naphthoic acid (32018-87-4) + 1-amino-naphthalene (134-32-7)

Guidance literature:

With sodium hydroxide; iron(II) sulfate;

Reference yield: 54.0%

4-Amino-1-naphthoic acid (32018-87-4) + benzyl chloroformate (501-53-1,94274-21-2) → 4-<<(benzyloxy)carbonyl>amino>-1-naphthoic acid (95092-75-4)

Guidance literature:

With potassium hydroxide; for 3h; Ambient temperature;

DOI:10.1248/cpb.32.3968

Reference yield: 27.0%

methanol (67-56-1) + 4-Amino-1-naphthoic acid (32018-87-4) → methyl 4-aminonaphthalene-1-carboxylate (157252-24-9)

Guidance literature:

With thionyl chloride; at 50 ℃; Inert atmosphere;

DOI:10.1021/acs.jmedchem.7b01154

upstream raw materials:

4-nitro-1-naphthoic acid

Downstream raw materials:

4-Ethoxycarbonyl-1-naphthylamine

4-<<(benzyloxy)carbonyl>amino>-1-naphthoic acid

4-chloro-1-naphthoic acid

1-amino-naphthalene