Cyclobutanecarbonitrile, 1-methyl-3-methylene-

Base Information

• Chemical Name: Cyclobutanecarbonitrile, 1-methyl-3-methylene-
• CAS No.: 32082-16-9
• Molecular Formula: C7H9N
• Molecular Weight: 107.155
• Mol file: 32082-16-9.mol

Synonyms:

Chemical Property of Cyclobutanecarbonitrile, 1-methyl-3-methylene-

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Cyclobutanecarbonitrile, 1-methyl-3-methylene-

There total 1 articles about Cyclobutanecarbonitrile, 1-methyl-3-methylene- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

3-methylenecyclobutanecarbonitrile (15760-35-7) + methyl iodide (74-88-4) → 1-methyl-3-methylenecyclobutane-1-carbonitrile (32082-16-9)

Guidance literature:

With n-butyllithium; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at -78 - 20 ℃; for 2h; Inert atmosphere;

Reference yield: 97.0%

1-methyl-3-methylenecyclobutane-1-carbonitrile (32082-16-9) → 1-methyl-3-methylidenecyclobutanecarboxylic acid (286442-86-2)

Guidance literature:

With water; potassium hydroxide; In ethanol; Reflux;

Reference yield: 71.0%

1-methyl-3-methylenecyclobutane-1-carbonitrile (32082-16-9) → 1-methyl-3-oxocyclobutane-1-carbonitrile (32082-17-0)

Guidance literature:

With sodium periodate; ruthenium(III) trichloride hydrate; In dichloromethane; water; acetonitrile; at 5 - 25 ℃; for 17h; Inert atmosphere;

upstream raw materials:

3-methylenecyclobutanecarbonitrile

methyl iodide

Downstream raw materials:

1-methyl-3-oxocyclobutane-1-carbonitrile

(R)-2-{4-chloro-N-{[(1s,3r)-3-cyano-3-methylcyclobutyl]methyl}-phenylsulfonamido}-5,5,5-trifluoropentanamide

(R)-2-{4-chloro-N-{[(1r,3s)-3-cyano-3-methylcyclobutyl]methyl}-phenylsulfonamido}-5,5,5-trifluoropentanamide

1-methyl-3-methylidenecyclobutanecarboxylic acid

Refernces

• 1、 -. "CYCLOBUTANE- AND AZETIDINE-CONTAINING MONO AND SPIROCYCLIC COMPOUNDS AS ALPHA V INTEGRIN INHIBITORS". Page/Page column 123; 124. . Retrieved 2018/05/27.
• 2、 -. "PYRROLO[2,3-D]PYRIMIDINE DERIVATIVES USEFUL FOR INHIBITING JANUS KINASE". Page/Page column 75; 76. . Retrieved 2016/02/29.