Phosphinic chloride, phenyl(phenylmethyl)-

Base Information

• Chemical Name: Phosphinic chloride, phenyl(phenylmethyl)-
• CAS No.: 32395-29-2
• Molecular Formula: C13H12ClOP
• Molecular Weight: 250.664
• Mol file: 32395-29-2.mol

Synonyms:

Chemical Property of Phosphinic chloride, phenyl(phenylmethyl)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Phosphinic chloride, phenyl(phenylmethyl)-

There total 9 articles about Phosphinic chloride, phenyl(phenylmethyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

(±)-benzyl(phenyl)phosphinic acid (7282-98-6) → benzylphenylphosphinous acid chloride (32395-29-2)

Guidance literature:

With thionyl chloride; In dichloromethane; Heating;

DOI:10.1021/jo052575q

Reference yield:

diethyl phenylphosphonite (1638-86-4) + benzyl bromide (100-39-0) → benzylphenylphosphinous acid chloride (32395-29-2)

Guidance literature:

With hydrogenchloride; thionyl chloride; Multistep reaction;

DOI:10.1021/ja9908016

Reference yield:

C17H22NP → benzylphenylphosphinous acid chloride (32395-29-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: hydrogen peroxide / acetone; H₂O / Heating

1.2: hydrochloric acid / acetone; H₂O

2.1: 89 percent / thionyl chloride / CH₂Cl₂ / Heating

With thionyl chloride; dihydrogen peroxide; In dichloromethane; water; acetone;

DOI:10.1021/jo052575q

upstream raw materials:

(±)-benzyl(phenyl)phosphinic acid

diethyl phenylphosphonite

benzyl bromide

Dichlorophenylphosphine

Downstream raw materials:

(D)-1,2:5,6-diisopropylidene-α-D-glucofuranosyl benzylphenylphosphinate

N-(benzylphenylphosphinoyl)hydroxylamine

p-methoxystilbene

Refernces

• 1、 Oliana, Marco,King, Frank,Horton, Peter N.,Hursthouse,Hii, King Kuok. "Practical synthesis of chiral vinylphosphine oxides by direct nucleophilic substitution. Stereodivergent synthesis of aminophosphine ligands". . p. 2472 - 2479. Retrieved 2007/10/03.
• 2、 Cevasco, Giorgio,Thea, Sergio. "Kinetic Study on the Alkaline Hydrolysis of Some Tetracoordinate PV Esters of 2,4-Dinitrophenol". . p. 1103 - 1106. Retrieved 2007/10/02.