4-Bromo-2-(trifluoromethyl)phenol

Base Information

• Chemical Name: 4-Bromo-2-(trifluoromethyl)phenol
• CAS No.: 50824-04-9
• Molecular Formula: C7H4BrF3O
• Molecular Weight: 241.007
• Hs Code.: 2908199090
• Mol file: 50824-04-9.mol

Synonyms:4-Bromo-2-(trifluoromethyl)benzenol;4-Bromo-2-(trifluoromethyl)phenol;

Chemical Property of 4-Bromo-2-(trifluoromethyl)phenol

Chemical Property:

• Vapor Pressure: 0.195mmHg at 25°C
• Melting Point: 83-85 °C
• Refractive Index: 1.505
• Boiling Point: 203.4 °C at 760 mmHg
• PKA: 7.41±0.43(Predicted)
• Flash Point: 76.8 °C
• PSA: 20.23000
• Density: 1.752 g/cm³
• LogP: 3.17350
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

4-Bromo-2-trifluoromethylphenol ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T
• Hazard Codes: T

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Bromo-2-(trifluoromethyl)phenol

There total 5 articles about 4-Bromo-2-(trifluoromethyl)phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-(trifluoromethyl)phenol (444-30-4) → 4-bromo-2-(trifluoromethyl)phenol (50824-04-9)

Guidance literature:

With bromine; trifluoroacetic acid; at 20 ℃; for 2h;

Reference yield: 81.0%

tetra-n-butylammonium tribromide + 2-(trifluoromethyl)phenol (444-30-4) → 4-bromo-2-(trifluoromethyl)phenol (50824-04-9)

Guidance literature:

With hydrogenchloride; In chloroform;

Reference yield:

4-bromo-1-methoxy-2-(trifluoromethyl)benzene (1514-11-0) → 4-bromo-2-(trifluoromethyl)phenol (50824-04-9)

Guidance literature:

With sodium hydrogencarbonate; In hydrogen bromide; acetic acid;

upstream raw materials:

2-(trifluoromethyl)phenol

4-bromo-1-methoxy-2-(trifluoromethyl)benzene

4-bromo-phenol

Langlois reagent

Downstream raw materials:

4-bromo-1-phenylmethoxy-2-(trifluoromethyl)benzene

4-bromo-1-ethoxy-2-trifluoromethylbenzene

C₁₃H₁₃BrF₃NO₂

3-fluoro-4'-((4-fluorobenzyl)oxy)-3'-(trifluoromethyl)-[1,1'-biphenyl]-4-carboxylic acid

Refernces

• 1、 Wang, Ligeng,Feng, Chun,Zhang, Yan,Hu, Jun. "Regioselective monobromination of phenols with KBr and ZnAl–BrO3?–layered double hydroxides". supporting information. . Retrieved 2020/02/22.
• 2、 -. "As the NS4B inhibitor benzofuran analogs (by machine translation)". Paragraph 0094; 0096; 0097; 0098; 0099. . Retrieved 2016/10/31.