Bis(cyclohexylmethyl)amine

Base Information

• Chemical Name: Bis(cyclohexylmethyl)amine
• CAS No.: 3309-27-1
• Molecular Formula: C14H27N
• Molecular Weight: 209.375
• DSSTox Substance ID: DTXSID90404679
• Nikkaji Number: J405.738D
• Wikidata: Q82208971
• Mol file: 3309-27-1.mol

Synonyms:bis(cyclohexylmethyl)amine;3309-27-1;1-cyclohexyl-N-(cyclohexylmethyl)methanamine;N,N-dicylohexylmethylamine;N,N-di-cyclohexylmethylamine;N,N-dicyclo-hexylmethylamine;SCHEMBL1679033;DTXSID90404679;JLURWBIBHMXAHE-UHFFFAOYSA-N;AKOS009007127;cyclohexyl-N-(cyclohexylmethyl)methanamine;EN300-54592;Z90509538

Chemical Property of Bis(cyclohexylmethyl)amine

Chemical Property:

• XLogP3: 4.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 4
• Exact Mass: 209.214349865
• Heavy Atom Count: 15
• Complexity: 137

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C1CCC(CC1)CNCC2CCCCC2

Technology Process of Bis(cyclohexylmethyl)amine

There total 34 articles about Bis(cyclohexylmethyl)amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

cyclohexane carbonitrile (766-05-2) → tris-(cyclohexylmethyl)-amine (3218-01-7) + N,N-dicyclohexylmethylamine (3309-27-1)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In cyclohexane; at 25 ℃; for 24h; under 760.051 Torr; Temperature;

DOI:10.1021/acs.joc.7b01823

Reference yield: 91.0%

Bis-(benzotriazol-1-yl-cyclohexyl-methyl)-amine (300679-86-1) → N,N-dicyclohexylmethylamine (3309-27-1)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; for 0.5h; Ambient temperature;

DOI:10.1055/s-1991-26551

Reference yield: 90.0%

carbon monoxide (201230-82-2) + cyclohexene (110-83-8) → N,N-dicyclohexylmethylamine (3309-27-1)

Guidance literature:

With ammonia; hydrogen; chloro(1,5-cyclooctadiene)rhodium(I) dimer; In chloroform; at 115 ℃; for 96h; under 87006.9 Torr;

DOI:10.1016/S0040-4020(98)83008-1

upstream raw materials:

1-nitromethyl-cyclohexene

tribenzylamine

cyclohexanecarbaldehyde

carbon monoxide

Refernces

• 1、 Vermaak, Vincent,Vosloo, Hermanus C.M.,Swarts, Andrew J.. "Chemoselective transfer hydrogenation of nitriles to secondary amines with nickel(II) catalysts". . . Retrieved 2021/07/25.
• 2、 -. "SUPPORTED HETEROGENEOUS CATALYST, PREPARATION AND USE THEREOF". Page/Page column 22. . Retrieved 2021/06/11.