Benzenebutanoic acid, 3-fluoro-4-methoxy-

Base Information

• Chemical Name: Benzenebutanoic acid, 3-fluoro-4-methoxy-
• CAS No.: 331-42-0
• Molecular Formula: C11H13FO3
• Molecular Weight: 212.221
• Mol file: 331-42-0.mol

Synonyms:

Chemical Property of Benzenebutanoic acid, 3-fluoro-4-methoxy-

Chemical Property:

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzenebutanoic acid, 3-fluoro-4-methoxy-

There total 3 articles about Benzenebutanoic acid, 3-fluoro-4-methoxy- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

γ-(3-fluoro-4-methoxy)-γ-oxobenzenebutanoic acid (347-63-7) → 4-(3-fluoro-4-methoxyphenyl)butyric acid (331-42-0)

Guidance literature:

With triethylsilane; trifluoroacetic acid; at 70 ℃; for 25h;

Reference yield:

1-fluoro-2-methoxybenzene (321-28-8) → 4-(3-fluoro-4-methoxyphenyl)butyric acid (331-42-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 76 percent / AlCl₃ / 1,2-dichloro-ethane / 0.33 h / 65 °C

2: 62 percent / 10percent aq. HClO₄, H₂ / 10percent Pd/C / ethanol; acetic acid / 3.5 h / 3102.9 Torr / Ambient temperature

With aluminium trichloride; perchloric acid; hydrogen; palladium on activated charcoal; In ethanol; acetic acid; 1,2-dichloro-ethane;

DOI:10.1021/jm00159a010

Reference yield:

→ 4-(3-fluoro-4-methoxyphenyl)butyric acid (331-42-0)

Guidance literature:

upstream raw materials:

γ-(3-fluoro-4-methoxy)-γ-oxobenzenebutanoic acid

1-fluoro-2-methoxybenzene

Downstream raw materials:

6-fluoro-7-methoxy-1-oximinotetralin tosylate

Refernces

• 1、 -. "4,5-DIHYDRONAPHTHO [1,2-b] THIOPHENE DERIVATIVE". Page/Page column 12. . Retrieved 2010/11/08.
• 2、 Weinstock, Joseph,Gaitanopoulos, Dimitri E.,Oh, Hye-Ja,Pfeiffer, Francis R.,Karash, Carole B.,et al.. "Synthesis and Dopaminergic Activity of Some Halogenated Mono- and Dihydroxylated 2-Aminotetralins". . p. 1615 - 1627. Retrieved 2007/10/02.