(R)-2-methylbutyraldehyde

Base Information

• Chemical Name: (R)-2-methylbutyraldehyde
• CAS No.: 33204-48-7
• Molecular Formula: C5H10O
• Molecular Weight: 86.1338
• DSSTox Substance ID: DTXSID90426270
• Nikkaji Number: J52.861G
• Wikidata: Q82239215
• Mol file: 33204-48-7.mol

Synonyms:(R)-2-methylbutyraldehyde;33204-48-7;(2R)-2-methylbutanal;(r)-2-methylbutanal;(A+/-)-2-methyl-butyraldehyde;DTXSID90426270;BYGQBDHUGHBGMD-RXMQYKEDSA-N

Chemical Property of (R)-2-methylbutyraldehyde

Chemical Property:

• XLogP3: 1.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 86.073164938
• Heavy Atom Count: 6
• Complexity: 41.2

Purity/Quality:

99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCC(C)C=O
• Isomeric SMILES: CC[C@@H](C)C=O

Technology Process of (R)-2-methylbutyraldehyde

There total 6 articles about (R)-2-methylbutyraldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(Z)-2-Butene (590-18-1) + carbon monoxide (201230-82-2) → pentanal (110-62-3) + (S)-2-methylbutyraldehyde (1730-97-8) + (R)-2-methylbutanal (33204-48-7)

Guidance literature:

With hydrogen; Rh(I)-(R,S)-BINAPHOS; at 60 ℃; for 2h; under 20520 Torr; Title compound not separated from byproducts;

DOI:10.1021/ja034447u

Reference yield:

1-butylene (106-98-9,9003-28-5) + carbon monoxide (201230-82-2) → pentanal (110-62-3) + (R)-2-methylbutanal (33204-48-7)

Guidance literature:

carbon monoxide; With dicarbonyl(acetylacotonato)rhodium(I); (R,R,R)-BOBPHOS; hydrogen; at 50 ℃; for 1h; under 7500.75 Torr; Autoclave;

1-butylene; In hexane; at 19 ℃; for 64h; under 1875.19 Torr; stereoselective reaction; Autoclave;

DOI:10.1002/anie.201811888

Reference yield:

1-butylene (106-98-9,9003-28-5) + carbon monoxide (201230-82-2) → pentanal (110-62-3) + (S)-2-methylbutyraldehyde (1730-97-8) + (R)-2-methylbutanal (33204-48-7)

Guidance literature:

With acetylacetonatodicarbonylrhodium(l); (R)-<2-(diphenylphosphino)-1,1'-binaphthalen-2'-yl><(S)-1,1'-binaphthalen-2,2'-diyl>phosphite>; hydrogen; In benzene; at 60 ℃; for 44h; under 76000 Torr;

DOI:10.1039/c39940000395

upstream raw materials:

(-)-2-Methylbutan-1-ol

(-)-2-methylbutyric acid

1-butylene

carbon monoxide

Downstream raw materials:

(-)-betaenone C

betaenone B

C₃₉H₅₂O₄

(4R)-4-benzyl-3-((2R,3S,4R)-3-hydroxy-2,4-dimethylhexanoyl)oxazolidin-2-one

Refernces

• 1、 Shibahara, Fumitoshi,Nozaki, Kyoko,Hiyama, Tamejiro. "Solvent-free asymmetric olefin hydroformylation catalyzed by highly cross-linked polystyrene-supported (R,S)-BINAPHOS-Rh(I) complex". . p. 8555 - 8560. Retrieved 2007/10/03.
• 2、 Higashizima, Takanori,Sakai, Nozomu,Nozaki, Kyoko,Takaya, Hidemasa. "Synthesis of New Chiral Phosphinephosphites Having 2-Diphenylphosphinobiphenyl-2'-yl Backbone and Their Use in Rh(I)-Catalyzed Asymmetric Hydroformylations". . p. 2023 - 2026. Retrieved 2007/10/02.