1-CHLORO-4-METHOXYISOQUINOLINE

Base Information

• Chemical Name: 1-CHLORO-4-METHOXYISOQUINOLINE
• CAS No.: 3336-60-5
• Molecular Formula: C10H8ClNO
• Molecular Weight: 193.633
• Hs Code.: 2933499090
• Mol file: 3336-60-5.mol

Synonyms:1-Chloro-4-methoxyisoquinoline;

Chemical Property of 1-CHLORO-4-METHOXYISOQUINOLINE

Chemical Property:

• Boiling Point: 333.135 °C at 760 mmHg
• Flash Point: 155.275 °C
• PSA: 22.12000
• Density: 1.268 g/cm³
• LogP: 2.89680
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

NLT 98% ^*data from raw suppliers

1-Chloro-4-methoxyisoquinoline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-CHLORO-4-METHOXYISOQUINOLINE

There total 7 articles about 1-CHLORO-4-METHOXYISOQUINOLINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4--methoxyisoquinoline N--oxide (76570-11-1) → 1-chloro-4-methoxyisoquinoline (3336-60-5)

Guidance literature:

With trichlorophosphate; In 1,2-dichloro-ethane;

Reference yield: 68.0%

→ 1-chloro-4-methoxyisoquinoline (3336-60-5)

Guidance literature:

Reference yield: 46.4%

1-chloro-4-isoquinolinol (3336-43-4) + diazomethyl-trimethyl-silane (18107-18-1) → 1-chloro-4-methoxyisoquinoline (3336-60-5)

Guidance literature:

In acetonitrile; at 0 - 20 ℃; for 2h;

upstream raw materials:

4-methoxy-isoquinolin-1-ol

trichlorophosphate

methyl iodide

1-chloro-4-isoquinolinol

Downstream raw materials:

decahydroisoquinoline

1-chloro-4-isoquinolinol

Refernces

• 1、 -. "Hepatitis C Virus Inhibitors". Paragraph 0150; 0151. . Retrieved 2015/11/02.
• 2、 -. "Hepatitis C Virus Inhibitors". Page/Page column. . Retrieved 2013/05/21.