1-Azaspiro[4.5]decan-2-one

Base Information

• Chemical Name: 1-Azaspiro[4.5]decan-2-one
• CAS No.: 5498-74-8
• Molecular Formula: C₉H₁₅NO
• Molecular Weight: 153.224
• Hs Code.: 2933790090
• Mol file: 5498-74-8.mol

Synonyms:NSC 63911

Chemical Property of 1-Azaspiro[4.5]decan-2-one

Chemical Property:

• Vapor Pressure: 0.000169mmHg at 25°C
• Boiling Point: 330.1°Cat760mmHg
• Flash Point: 192.3°C
• PSA: 29.10000
• Density: 1.05g/cm³
• LogP: 1.92810

Purity/Quality:

99% ^*data from raw suppliers

1-Azaspiro[4.5]decan-2-one 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-Azaspiro[4.5]decan-2-one

There total 34 articles about 1-Azaspiro[4.5]decan-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

1-(2-methyl-benzyl)-1-aza-spiro[4.5]decan-2-one (397870-25-6) → 2-oxo-1-azaspiro<4.5>decane (5498-74-8)

Guidance literature:

With ammonia; sodium; In ethanol; at -78 ℃;

DOI:10.1055/s-2001-17475

Reference yield: 91.0%

N-[{3,5-bis(trifluoromethyl)benzoyl}oxy]-3-cyclohexylpropanamide → 2-oxo-1-azaspiro<4.5>decane (5498-74-8)

Guidance literature:

With C₂₂H₂₆ClIrN₂O₃; potassium carbonate; sodium tetrakis[(3,5-di-trifluoromethyl)phenyl]borate; In 2,2,2-trifluoroethanol; at 40 ℃; for 12h; Sealed tube;

DOI:10.1021/acs.orglett.9b00791

Reference yield: 90.0%

2-Oxo-1-aza-spiro[4.5]decane-1-carboxylic acid methyl ester (76403-47-9) → 2-oxo-1-azaspiro<4.5>decane (5498-74-8)

Guidance literature:

With trimethylsilyl iodide; In chloroform; at 60 ℃; for 15h;

DOI:10.1021/jo00321a017

upstream raw materials:

1-(2-methoxycarbonylethyl)-1-nitrocyclohexane

cyclopropylidenecyclohexane

spiro[3.5]nonan-1-one

2-Oxo-1-aza-spiro[4.5]decane-1-carboxylic acid methyl ester

Downstream raw materials:

10-[2-(1-aza-spiro[4.5]dec-1-yl)-ethyl]-10H-phenothiazine

cyclopent-2-enyl-phenyl-acetic acid-[2-(1-aza-spiro[4.5]dec-1-yl)-ethyl ester]

N-(1-aza-spiro[4.5]dec-2-yliden)-anthranilic acid

1-azaspiro[4.5]decane

Refernces

• 1、 Kweon, Jeonguk,Chang, Sukbok. "Highly Robust Iron Catalyst System for Intramolecular C(sp3)?H Amidation Leading to γ-Lactams". supporting information. p. 2909 - 2914. Retrieved 2020/12/11.
• 2、 Chang, Sukbok,Jung, Hoimin,Keum, Hyeyun,Kweon, Jeonguk. "Tuning Triplet Energy Transfer of Hydroxamates as the Nitrene Precursor for Intramolecular C(sp3)-H Amidation". supporting information. p. 5811 - 5818. Retrieved 2020/04/10.