2-Naphthalenepropanoic acid, b-methyl-

Base Information

• Chemical Name: 2-Naphthalenepropanoic acid, b-methyl-
• CAS No.: 33417-02-6
• Molecular Formula: C14H14O2
• Molecular Weight: 214.264
• Mol file: 33417-02-6.mol

Synonyms:

Chemical Property of 2-Naphthalenepropanoic acid, b-methyl-

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Naphthalenepropanoic acid, b-methyl-

There total 1 articles about 2-Naphthalenepropanoic acid, b-methyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

but-3-enoic acid (625-38-7) + naphthalene-2-boronic acid (32316-92-0) → 4-(2-naphthyl)butyric acid (782-28-5) + 3-(naphthalen-2-yl)butanoic acid (33417-02-6)

Guidance literature:

With bis(1,5-cyclooctadiene)nickel ⁽⁰⁾; potassium tert-butylate; butan-1-ol; at 40 ℃; Overall yield = 99 percent; Overall yield = 21.2 mg; regioselective reaction; Sealed tube;

DOI:10.1002/anie.202010840

Reference yield: 94.0%

3-(naphthalen-2-yl)butanoic acid (33417-02-6) + ethyl 2-(benzoylhydrazono)ethanoate (16691-19-3) → (R)-ethyl 1-benzamido-4-(naphthalen-2-yl)-6-oxo-1,2,3,6-tetrahydropyridine-2-carboxylate

Guidance literature:

With 3,5,3',5'-tetra-tert-butyl-4,4'-diphenoquinone; C₂₁H₂₂N₃O⁽¹⁺⁾*BF₄^(1-); caesium carbonate; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In tetrahydrofuran; at 25 ℃; for 12h; enantioselective reaction; Inert atmosphere; Schlenk technique;

DOI:10.1021/acs.orglett.5b03223

Reference yield: 88.0%

3-(naphthalen-2-yl)butanoic acid (33417-02-6) + C12H14N2O3 → ethyl (R)-1-(3-methylbenzamido)-4-(naphthalen-2-yl)-6-oxo-1,2,3,6-tetrahydropyridine-2-carboxylate

Guidance literature:

With 3,5,3',5'-tetra-tert-butyl-4,4'-diphenoquinone; C₂₁H₂₂N₃O⁽¹⁺⁾*BF₄^(1-); caesium carbonate; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In tetrahydrofuran; at 25 ℃; for 12h; enantioselective reaction; Inert atmosphere; Schlenk technique;

DOI:10.1021/acs.orglett.5b03223

upstream raw materials:

but-3-enoic acid

naphthalene-2-boronic acid

Refernces