Technology Process of (R)-1-Pentyne-3-ol
There total 1 articles about (R)-1-Pentyne-3-ol which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
phosphate buffer; Pseudomonas lipase Amano AH; catechin;
at 30 ℃;
for 48h;
pH=7.0;
Further Variations:;
Reagents;
Product distribution;
DOI:10.1016/S0957-4166(02)00121-0
- Guidance literature:
-
diisopropyl(phenylethynyl)silane;
With
N-Bromosuccinimide;
In
dichloromethane;
Inert atmosphere;
(3R)-3-hydroxypentinol;
With
dmap; triethylamine;
In
dichloromethane;
DOI:10.1021/ol8004936
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: tetrakis(triphenylphosphine) palladium(0); tert-butylamine; copper(l) iodide / methanol; benzene / 3 h / 0 - 20 °C
2.1: zinc; copper diacetate; silver nitrate / methanol; water / 13 h / 45 °C / Inert atmosphere
3.1: sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid / dichloromethane / 1 h / 0 °C
3.2: 1 h / 0 °C
4.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 1.33 h / 0 °C
With
copper(l) iodide; tetrakis(triphenylphosphine) palladium(0); di-isopropyl azodicarboxylate; copper diacetate; sodium hydrogencarbonate; silver nitrate; tert-butylamine; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; zinc;
In
tetrahydrofuran; methanol; dichloromethane; water; benzene;
4.1: |Mitsunobu Displacement;
DOI:10.1039/c8ob03196g
