Methyl 3-(1-IMidazolyl)benzoate

Base Information

• Chemical Name: Methyl 3-(1-IMidazolyl)benzoate
• CAS No.: 335255-85-1
• Molecular Formula: C11H10N2O2
• Molecular Weight: 202.20900
• Hs Code.: 2933290090
• Mol file: 335255-85-1.mol

Synonyms:METHYL 3-PYRROL-1-YLMETHYL-BENZOATE;

Chemical Property of Methyl 3-(1-IMidazolyl)benzoate

Chemical Property:

• PSA: 44.12000
• LogP: 1.65890
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%min ^*data from raw suppliers

Methyl 3-(1-imidazolyl)benzoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methyl 3-(1-IMidazolyl)benzoate

There total 4 articles about Methyl 3-(1-IMidazolyl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

methanol (67-56-1) + 3-(1H-imidazol-1-yl)-benzoic acid (108035-47-8) → methyl 3-(1’H-imidazol-1’-yl)benzoate (335255-85-1)

Guidance literature:

With sulfuric acid; Heating;

DOI:10.1016/j.bmcl.2007.12.005

Reference yield: 58.0%

Methyl 3-aminobenzoate (4518-10-9) + formaldehyd (50-00-0,30525-89-4,61233-19-0) + Glyoxal (131543-46-9,107-22-2) → methyl 3-(1’H-imidazol-1’-yl)benzoate (335255-85-1)

Guidance literature:

Methyl 3-aminobenzoate; Glyoxal; In methanol; water; at 20 ℃; for 18h;

formaldehyd; With ammonium chloride; In methanol; water; for 1h; Reflux;

With hydrogenchloride; In methanol; water; for 5h; Reflux;

DOI:10.1039/c3md00110e

Reference yield:

Methyl 3-aminobenzoate (4518-10-9) → methyl 3-(1’H-imidazol-1’-yl)benzoate (335255-85-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: aq. methanol / 16 h / 20 °C

2.1: aq. NH₄Cl / methanol / 1 h / Heating

2.2: aq. H₃PO₄ / methanol / Heating

With ammonium chloride; In methanol;

DOI:10.1055/s-2003-42444

upstream raw materials:

formaldehyd

Methyl 3-aminobenzoate

methanol

3-(1H-imidazol-1-yl)-benzoic acid

Downstream raw materials:

3-(3-Imidazol-1-yl-phenyl)-3-oxo-propionic Acid tert-butyl Ester

5-benzyloxy-1-(tert-butoxycarbonylamino)-2-{3’-[3''-(1'''H-imidazol-1'''-yl)phenyl]-3’-oxopropanamido}-4-(trifluoromethyl)benzene

4-[3’-(1''H-imidazol-1''-yl)phenyl]-7-methoxy-8-(4'''-(trimethylstannyl)phenyl)-2,3-dihydro-1H-1,5-benzodiazepin-2-one

4-[3’-(1''H-imidazol-1''yl)phenyl]-8-[4'''-(trimethylstannyl)phenyl]-2,3-dihydro-1H-1,5-benzodiazepin-2-one

Refernces

• 1、 Woltering, Thomas J.,Adam, Geo,Wichmann, Juergen,Goetschi, Erwin,Kew, James N.C.,Knoflach, Frederic,Mutel, Vincent,Gatti, Silvia. "Synthesis and characterization of 8-ethynyl-1,3-dihydro-benzo[b][1,4]diazepin-2-one derivatives: Part 2. New potent non-competitive metabotropic glutamate receptor 2/3 antagonists". . p. 1091 - 1095. Retrieved 2008/09/20.