N-(4-Methoxyphenyl)-4-MethylbenzaMide, 97%

Base Information

• Chemical Name: N-(4-Methoxyphenyl)-4-MethylbenzaMide, 97%
• CAS No.: 33667-91-3
• Molecular Formula: C15H15NO2
• Molecular Weight: 241.29
• Hs Code.: 2924299090
• Mol file: 33667-91-3.mol

Synonyms:4-methyl-benzoic acid p-anisidide;4-methoxyphenyl pivalamide;N-pivaloyl-p-anisidine;p-Toluylsaeure-4-methoxyanilid;

Chemical Property of N-(4-Methoxyphenyl)-4-MethylbenzaMide, 97%

Chemical Property:

• Melting Point: 71-73 °C(Solv: dichloromethane (75-09-2))
• Boiling Point: 318.2±35.0 °C(Predicted)
• PKA: 13.17±0.70(Predicted)
• PSA: 41.82000
• Density: 1.156±0.06 g/cm3(Predicted)
• LogP: 3.63990

Purity/Quality:

99% ^*data from raw suppliers

N-(4-Methoxyphenyl)-4-methylbenzamide 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(4-Methoxyphenyl)-4-MethylbenzaMide, 97%

There total 29 articles about N-(4-Methoxyphenyl)-4-MethylbenzaMide, 97% which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

para-iodoanisole (696-62-8) + para-methylbenzamide (619-55-6) → N-(4-methoxyphenyl)-4-methylbenzamide (33667-91-3)

Guidance literature:

With potassium phosphate tribasic trihydrate; N,N`-dimethylethylenediamine; In toluene; at 110 ℃; for 10h; Inert atmosphere;

DOI:10.1002/cjoc.201090374

Reference yield: 97.0%

phenyl p-methylbenzoate (1900-85-2) + 4-methoxy-aniline (104-94-9) → N-(4-methoxyphenyl)-4-methylbenzamide (33667-91-3)

Guidance literature:

With C₄₀H₅₄ClN₂Pd; caesium carbonate; In tetrahydrofuran; water; at 40 ℃; for 4h; Glovebox; Inert atmosphere;

DOI:10.1021/acs.joc.7b02588

Reference yield: 95.0%

4-methoxy-aniline (104-94-9) + p-Toluic acid (99-94-5) → N-(4-methoxyphenyl)-4-methylbenzamide (33667-91-3)

Guidance literature:

p-Toluic acid; With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; at 20 ℃; for 0.166667h;

4-methoxy-aniline; at 20 ℃; for 1h;

DOI:10.1039/c8ob00653a

upstream raw materials:

4-methyl-benzoyl chloride

4-methoxy-aniline

benzoic-p-methylbenzoic anhydride

3,4-bis(4-methylphenyl)-1,2,5-oxadiazole-N-oxide

Downstream raw materials:

4-methyl-N-(4-methoxyphenyl)benzothioamide

1-(4-Methoxyphenyl)-5-(4-methylphenyl)-1H-tetrazol

N-[(benzotriazol-1-yl)(4-methylphenyl)methylidene]-4-methoxyaniline

2-p-Tolyl-benzothiazol-6-ol

Refernces

• 1、 Wilson, Kirsty L.,Murray, Jane,Jamieson, Craig,Watson, Allan J. B.. "Cyrene as a bio-based solvent for HATU mediated amide coupling". . p. 2851 - 2854. Retrieved 2018.
• 2、 Angeles-Beltrán, Deyanira,Mendoza-Espinosa, Daniel,Rendón-Nava, David,Rheingold, Arnold L.. "Palladium(II) Complexes of a Neutral CCC-Tris(N-heterocyclic carbene) Pincer Ligand: Synthesis and Catalytic Applications". supporting information. p. 2166 - 2177. Retrieved 2021/07/20.
• 3、 -. "Method for synthesizing amide derivative under catalysis of vanadium". Paragraph 0013-0015; 0065-0067. . Retrieved 2021/02/10.