2-AMINO-4'-TRIFLUOROMETHYLACETOPHENONE HYDROCHLORIDE

Base Information

• Chemical Name: 2-AMINO-4'-TRIFLUOROMETHYLACETOPHENONE HYDROCHLORIDE
• CAS No.: 339-58-2
• Molecular Formula: C9H8F3NO.ClH
• Molecular Weight: 239.625
• Hs Code.: 2922399090
• Mol file: 339-58-2.mol

Synonyms:QC-3700;2-amino-1-[4-(trifluoromethyl)phenyl]-1-ethanone hydrogen chloride;2-Amino-4'-trifluoromethylacetophenone HCl;FD7405;2-Amino-1-(4-trifluormethyl-phenyl)-aethanon,Hydrochlorid;

Chemical Property of 2-AMINO-4'-TRIFLUOROMETHYLACETOPHENONE HYDROCHLORIDE

Chemical Property:

• PSA: 43.09000
• LogP: 3.34910
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C

Purity/Quality:

99%, ^*data from raw suppliers

2-Amino-1-(4-(trifluoromethyl)phenyl)ethanonehydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-AMINO-4'-TRIFLUOROMETHYLACETOPHENONE HYDROCHLORIDE

There total 3 articles about 2-AMINO-4'-TRIFLUOROMETHYLACETOPHENONE HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2-bromo-1-[4-(trifluoromethyl)phenyl]ethanone (383-53-9) → 2-amino-1-[4-(trifluoromethyl)phenyl]-1-ethanone hydrogen chloride (339-58-2)

Guidance literature:

2-bromo-1-[4-(trifluoromethyl)phenyl]ethanone; With sodium diformamide; In acetonitrile; at 20 - 70 ℃; for 4h;

With hydrogenchloride; In ethanol; water; for 1.5h; Reflux;

Reference yield:

2-azido-1-[4-(trifluoromethyl)phenyl]-1-ethanone (874813-04-4) → 2-amino-1-[4-(trifluoromethyl)phenyl]-1-ethanone hydrogen chloride (339-58-2)

Guidance literature:

With hydrogenchloride; palladium 10% on activated carbon; hydrogen; In methanol; water; at 20 ℃; for 21h; Cooling with NaCl-ice;

DOI:10.1021/ja201543h

Reference yield:

→ 2-amino-1-[4-(trifluoromethyl)phenyl]-1-ethanone hydrogen chloride (339-58-2)

Guidance literature:

upstream raw materials:

2-azido-1-[4-(trifluoromethyl)phenyl]-1-ethanone

2-bromo-1-[4-(trifluoromethyl)phenyl]ethanone

Downstream raw materials:

(R)-N-[2-hydroxy-2-{4-(trifluoromethyl)phenyl}ethyl]benzamide

C₂₅H₂₂F₃NO₄

C₂₅H₂₂F₃NO₄

(R)-2-phenyl-5-[4-(trifluoromethyl)phenyl]oxazoline

Refernces

• 1、 -. "DOPAMINE D3 RECEPTOR ANTAGONISTS HAVING A MORPHOLINE MOIETY". Paragraph 0254. . Retrieved 2018/11/21.
• 2、 -. "P70 S6 KINASE INHIBITORS". Page/Page column 16-17. . Retrieved 2009/01/20.