Amino-PEG5-alcohol

Base Information

• Chemical Name: Amino-PEG5-alcohol
• CAS No.: 34188-11-9
• Molecular Formula: C10H23NO5
• Molecular Weight: 237.296
• Hs Code.: 2918999090
• Mol file: 34188-11-9.mol

Synonyms:3,6,9,12,15-pentaoxapentadecyl amine;2-(2-{2-[2-(2-Amino-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethanol;O-(2-Amino-aethyl)-tetraaethylenglykol;Monoethanolamine 4 EO;O-(2-amino-ethyl)-tetraethylene glycol;

Chemical Property of Amino-PEG5-alcohol

Chemical Property:

• Boiling Point: 118 °C (0.01 mmHg)
• PKA: 14.36±0.10(Predicted)
• PSA: 83.17000
• Density: 1.077±0.06 g/cm3(Predicted)
• LogP: -0.29590
• Solubility.: Soluble in Water, DMSO, DMF, DCM

Purity/Quality:

98%,99%, ^*data from raw suppliers

Amino-PEG5-alcohol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Amino-PEG5-alcohol is a useful research chemical.
• Description: Amino-PEG5-alcohol is an aqueousr soluble PEG linker with one amine and one hydroxyl group. The amine group is reactive with carboxylic acids, activated NHS esters etc. The hydroxyl group enables further derivatization or replacement with other reactive functional groups.

Technology Process of Amino-PEG5-alcohol

There total 8 articles about Amino-PEG5-alcohol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethoxy]ethanol (86770-68-5) → 2-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethoxy]ethanol (34188-11-9)

Guidance literature:

With 5%-palladium/activated carbon; hydrogen; In ethanol; at 20 ℃; for 48h; under 775.743 Torr;

Reference yield: 92.0%

[2-(2-{2-[2-(2-Azido-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethoxymethyl]-benzene (86770-72-1) → 2-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethoxy]ethanol (34188-11-9)

Guidance literature:

With hydrogen; palladium;

Reference yield:

2-(2-{2-[2-(2-benzyloxyethoxy)ethoxy]ethoxy}ethoxy)ethanol (57671-28-0,1201808-31-2) → 2-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethoxy]ethanol (34188-11-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 86 percent / SOCl₂ / 18 h / 80 °C

2: 96 percent / NaN₃

3: 92 percent / H₂ / Pd

With thionyl chloride; sodium azide; hydrogen; palladium;

upstream raw materials:

Pentaethylene glycol

2-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethoxy]ethanol

[2-(2-{2-[2-(2-Azido-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethoxymethyl]-benzene

2-(2-{2-[2-(2-benzyloxyethoxy)ethoxy]ethoxy}ethoxy)ethanol

Downstream raw materials:

2-[2-[2-[2-[2-[2-(tert-butoxycarbonylamino)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]acetic acid

tert-butyl N-[2-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethoxy]ethyl]carbamate

2-(14-hydroxy-3,6,9,12-tetraoxatetradec-1-yl)-1H-isoindole-1,3(2H)-dione

C₁₇H₂₇NO₆

Refernces

• 1、 Murray, James,Nowak, Dominika,Pukenas, Laurynas,Azhar, Rizuan,Guillorit, Mathieu,Waelti, Christoph,Critchley, Kevin,Johnson, Steven,Bon, Robin S.. "Solid phase synthesis of functionalised SAM-forming alkanethiol- oligoethyleneglycols". . p. 3741 - 3744. Retrieved 2014/06/10.
• 2、 Gartiser, Thierry,Selve, Claude,Mansuy, Laurence,Robert, Alain,Delpuech, Jean-Jacques. "CHIMIE DES OLIGOETHYLENE-GLYCOLS: SYNTHESE DE TENSIO-ACTIFS NON IONIQUES POLYFLUORES MONODISPERSES". . p. 2672 - 2691. Retrieved 2007/10/02.