(S)-2-Amino-4-methylpentanoic acid sodium salt

Base Information

• Chemical Name: (S)-2-Amino-4-methylpentanoic acid sodium salt
• CAS No.: 34237-21-3
• Molecular Formula: C₆H₁₂NO₂*Na
• Molecular Weight: 153.157
• Mol file: 34237-21-3.mol

Synonyms:

Chemical Property of (S)-2-Amino-4-methylpentanoic acid sodium salt

Chemical Property:

• PSA: 66.15000
• LogP: -0.19000

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-Amino-4-methylpentanoic acid sodium salt

There total 2 articles about (S)-2-Amino-4-methylpentanoic acid sodium salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

L-leucine (61-90-5,21675-61-6,25248-98-0,70-45-1) → (L)-leucine sodium salt (34237-21-3,67607-44-7,118604-74-3)

Guidance literature:

With sodium hydroxide;

DOI:10.1021/jp105255b

Reference yield:

N-(1-methyl-2-ethoxycarbonylvinyl)-L-leucine sodium salt (32256-50-1,80180-51-4) → (L)-leucine sodium salt (34237-21-3,67607-44-7,118604-74-3)

Guidance literature:

With water; at 25 ℃; Rate constant; hydrolysis at pH 7.4;

DOI:10.1248/cpb.29.1998

Reference yield: 94.0%

(L)-leucine sodium salt (34237-21-3,67607-44-7,118604-74-3) + (Z)-4-benzylidene-2-methyl-5(4H)-oxazolone (38879-46-8) → Ac-ΔPhe-(S)-Leu-OH (57744-46-4)

Guidance literature:

DOI:10.1016/S0040-4020(01)87539-6

upstream raw materials:

N-(1-methyl-2-ethoxycarbonylvinyl)-L-leucine sodium salt

L-leucine

Downstream raw materials:

N-octadecanoyl leucine

Ac-ΔPhe-(S)-Leu-OH

Diphenylborinsaeure-L-leucin-anhydrid

(S)-2-(2-hydroxybenzylamino)-4-methylpentanoic acid

Refernces

• 1、 Chen, Gong,Ju, Yuan,Yang, Tao,Li, Zicheng,Ang, Wei,Sang, Zitai,Liu, Jie,Luo, Youfu. "Natural amino acid salt catalyzed aldol reactions of isatins with ketones: highly enantioselective construction of 3-alkyl-3-hydroxyindolin-2-ones". . p. 943 - 947. Retrieved 2015/09/01.
• 2、 Murakami,Yata,Tamauchi,Nakai,Yamazaki,Kamada. "Studies on absorption promoters for rectal delivery preparations. I. Promoting efficacy of enamine derivatives of amino acid for the rectal absorption of β-lactam antibiotics in rabbits". . p. 1998 - 2004. Retrieved 2007/10/02.